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Brief Title: Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

MAIN-CAV: Phase III Randomized Trial of Maintenance Cabozantinib and Avelumab vs Maintenance Avelumab After First-Line Platinum-Based Chemotherapy in Patients With Metastatic Urothelial Cancer

INTRODUCTION

  • Org Study ID: NCI-2021-11166
  • Secondary ID: NCI-2021-11166, A032001, A032001, U10CA180821
  • NTC ID: NCT05092958
  • Sponsor: National Cancer Institute (NCI)

BRIEF SUMMARY

This phase III trial compares the effect of adding cabozantinib to avelumab versus avelumab alone in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib and avelumab together may further shrink the cancer or prevent it from returning/progressing.

DETAILED DESCRIPTION

PRIMARY OBJECTIVE:

I. To evaluate the effect of cabozantinib S-malate (cabozantinib) in combination with avelumab on overall survival (OS) compared to avelumab alone in patients with metastatic urothelial cancer (mUC) who did not progress during first-line platinum-based chemotherapy therapy, i.e. patients who had complete response (CR), partial response (PR) or stable disease (SD) after completion of first line platinum-based chemotherapy.

SECONDARY OBJECTIVES:

I. To evaluate the effect of cabozantinib in combination with avelumab on progression-free survival (PFS) compared to avelumab alone for maintenance treatment following initial first-line treatment in patients who had a CR, PR or SD upon completion of first-line platinum-based chemotherapy.

II. To evaluate the safety and tolerability of cabozantinib in combination with avelumab in mUC compared to avelumab alone for maintenance treatment following initial first-line treatment in patients who had a CR, PR or SD upon completion of first-line platinum-based chemotherapy.

III. To evaluate activity of cabozantinib in combination with avelumab based on Response Evaluation Criteria in Solid Tumors (RECIST) compared to avelumab alone for maintenance treatment following initial first-line treatment in patients who had a CR, PR or SD upon completion of first-line platinum-based chemotherapy.

IV. Results of the primary analysis will be examined for consistency, while accounting for the stratification factors and/or covariates of baseline quality of life (QOL) and fatigue.

V. To evaluate the activity of cabozantinib in combination with avelumab compared to avelumab alone based on PD-L1 status of patients' tumors.

QUALITY OF LIFE (QOL) OBJECTIVES:

I. To compare quality-adjusted survival between patients randomized to receive cabozantinib and avelumab vs. avelumab alone using the European Quality of Life Five Dimension Five Level Scale Questionnaire (EQ-5D-5L).

II. To compare patient-reported fatigue as assessed by the Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue 4a from baseline through 12 months between patients randomized to receive cabozantinib and avelumab versus (vs.) avelumab alone.

III. To compare patient-reported global health status/quality of life as assessed by the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-Core (C)30 from baseline through 12 months between patients randomized to receive cabozantinib and avelumab vs. avelumab alone.

IV. To compare scale scores of the EORTC QLQ-Bladder Cancer Muscle-Invasive (BLM)30 (urinary symptoms, urostomy problems, catheter problems, future perspectives, abdominal bloating and flatulence, body image, sexual function) at 3, 6, 12, 18, and 24 months between patients randomized to receive cabozantinib and avelumab vs. avelumab alone.

V. To compare scale scores of the EORTC QLQ-C30 (global health status/quality of life; physical, role, emotional, cognitive, and social function; symptoms) at 3, 6, 12, 18, and 24 months between patients randomized to receive cabozantinib and avelumab vs. avelumab alone.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive avelumab intravenously (IV) over 60 minutes on days 1 and 15 of each cycle. Cycles repeat every 28 days for 24 months in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive avelumab IV over 60 minutes on days 1 and 15 of each cycle and cabozantinib orally (PO) daily. Cycles repeat every 28 days for 24 months in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed every 30 days through 90 days, then every 3 months for 5 years.

  • Overall Status
    Recruiting
  • Start Date
    March 10, 2022
  • Phase
    Phase 3
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Overall survival (OS)

Primary Outcome 1 - Timeframe: Time from randomization until death due to any cause, assessed up to 5 years

CONDITION

  • Advanced Bladder Urothelial Carcinoma
  • Advanced Renal Pelvis Urothelial Carcinoma
  • Advanced Ureter Urothelial Carcinoma
  • Advanced Urethral Urothelial Carcinoma
  • Metastatic Bladder Urothelial Carcinoma
  • Metastatic Renal Pelvis Urothelial Carcinoma
  • Metastatic Ureter Urothelial Carcinoma
  • Metastatic Urethral Urothelial Carcinoma
  • Stage III Bladder Cancer AJCC v8
  • Stage III Renal Pelvis and Ureter Cancer AJCC v8
  • Stage III Renal Pelvis Cancer AJCC v8
  • Stage III Ureter Cancer AJCC v8
  • Stage III Urethral Cancer AJCC v8
  • Stage IIIA Bladder Cancer AJCC v8
  • Stage IIIB Bladder Cancer AJCC v8
  • Stage IV Bladder Cancer AJCC v8
  • Stage IV Renal Pelvis and Ureter Cancer AJCC v8
  • Stage IV Renal Pelvis Cancer AJCC v8
  • Stage IV Ureter Cancer AJCC v8
  • Stage IV Urethral Cancer AJCC v8
  • Stage IVA Bladder Cancer AJCC v8
  • Stage IVB Bladder Cancer AJCC v8

ELIGIBILITY

Inclusion Criteria:
Histologically or cytologically-confirmed diagnosis of advanced or metastatic urothelial cancer of the renal pelvis, ureter, bladder, or urethra (transitional cell and mixed transitional/non-transitional cell histologies except for small-cell histology), including N3 only disease prior to start of first-line platinum-based chemotherapy

- Prior first-line treatment must have consisted of 4-6 cycles of 1st-line therapy (platinum-based chemotherapy; gemcitabine-cisplatin, gemcitabine-carboplatin, methotrexate, vinblastine, doxorubicin and cisplatin [MVAC] or dose-dense [dd]MVAC)

- No more than 1 line of prior chemotherapy for metastatic or locally advanced disease (neoadjuvant or adjuvant chemotherapy will be allowed if given 12 or more months prior to registration)

- Tumor objective response of CR, PR, or SD upon completion of first line platinum-based chemotherapy

- The last dose of first-line chemotherapy must have been received no less than 3 weeks, and no more than 10 weeks, prior to randomization in the present study

- No prior immunotherapy with IL-2, IFN-alpha, or an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or CTLA-4 antibody (including ipilimumab), or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways

- Age >= 18 years

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

- Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects
Women of childbearing potential must have a negative pregnancy test =< 14 days prior to registration.
Women of childbearing potential include women who have experienced menarche and who have not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or are not postmenopausal. Post menopause is defined as amenorrhea >= 12 consecutive months. Note: women who have been amenorrheic for 12 or more months are still considered to be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy, antiestrogens, ovarian suppression or any other reversible reason
No use of immunosuppressive medication within 7 days prior to randomization except:
Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra-articular injection);

- Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; - Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication) - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial - Active autoimmune disease that might deteriorate when receiving an immunostimulatory agent. Patients with diabetes type I, vitiligo, psoriasis, or hypo or hyperthyroid disease not requiring immunosuppressive treatment are eligible - Absolute neutrophil count (ANC) >= 1,000/mm^3

- Platelet count >= 100,000/mm^3

- Hemoglobin >= 8 g/dL

- Calculated (Calc.) creatinine clearance >= 30 mL/min

- Total serum bilirubin =< 1.5 x upper limit of normal (ULN) - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN (or =< 5 x ULN for patients with liver metastases or Gilbert's disease) - Urine protein creatinine (UPC) ratio =< 1 or 24-hour protein < 1 g
Exclusion Criteria:
No known symptomatic central nervous system (CNS) metastases. Patients with previously diagnosed CNS metastases are eligible if they have completed their treatment and have recovered from the acute effects of radiation therapy or surgery prior to randomization, have discontinued corticosteroid treatment for at least 2 weeks, and are neurologically stable. Baseline brain imaging with contrast-enhanced CT or magnetic resonance imaging (MRI) scans for subjects with known brain metastases is required to confirm eligibility

- No major surgery within 4 weeks prior to randomization. Subjects must have complete wound healing from surgery before randomization. Subjects with clinically relevant ongoing complications from prior surgery are not eligible

- No palliative radiotherapy within 48 hours prior to patient randomization

- No hemoptysis of >= 0.5 teaspoon (2.5 mL) of red blood, clinically significant hematuria, hematemesis, coagulopathy, or other history of significant bleeding (e.g. pulmonary hemorrhage) within 3 months before randomization

- No known cavitating pulmonary lesion(s) or known endobronchial disease manifestation

- No administration of a live, attenuated vaccine within 30 days prior to randomization. The use of inactivated (killed) vaccines for the prevention of infectious disease is permitted. The use of COVID-19 vaccines is permitted
No uncontrolled, significant intercurrent or recent illness including, but not limited to, the following conditions:
Cardiovascular disorders including:
Congestive heart failure (CHF): New York Heart Association (NYHA) class III (moderate) or class IV (severe) at the time of screening.

- Concurrent uncontrolled hypertension defined as sustained blood pressure (BP) > 150 mm Hg systolic, or > 90 mm Hg diastolic despite optimal antihypertensive treatment.

- The subject has a corrected QT interval calculated by the Fridericia formula (QTcF) > 500 ms within 28 days before randomization. Note: if initial QTcF is found to be > 500 ms, two additional electrocardiograms(EKGs) separated by at least 3 minutes should be performed. If the average of these three consecutive results for QTcF is =< 500 ms, the subject meets eligibility in this regard. - Any history of congenital long QT syndrome. - Stroke, transient ischemic attack (TIA), myocardial infarction, or other symptomatic ischemic event or thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism (DVT/PE) within 6 months before randomization. Subjects with a diagnosis of incidental, subsegmental PE or DVT within 6 months are allowed if asymptomatic and stable at screening and treated with low molecular weight heparin (LMWH) or the direct factor Xa inhibitors rivaroxaban, edoxaban, or apixaban for at least 1 week before randomization. Non-symptomatic white matter disease in the brain is acceptable. - No significant gastrointestinal disorders, particularly those associated with a high risk of perforation or fistula formation including unresolved active peptic ulcer disease, cholecystitis, diverticulitis, symptomatic cholangitis or appendicitis, or malabsorption syndrome within 28 days of randomization.
No other clinically significant disorders such as:
Any active infection requiring systemic treatment within 14 days before randomization. Subjects receiving oral (including prophylactic) antibiotics with no symptoms of infection at randomization are eligible.

- Serious non-healing wound/ulcer/bone fracture within 28 days before randomization

- History of organ or allogeneic stem cell transplant

- No persisting toxicity related to prior therapy grade > 2 constituting a safety risk based on the investigator's judgment.

- No diagnosis of any other malignancy within 3 years prior to randomization, except for locally curable cancers that have been adequately treated such as basal cell or squamous cell skin cancer, or carcinoma in situ of the breast or of the cervix, Gleason < 7 prostate cancer on surveillance without any plans for treatment intervention (e.g., surgery, radiation, or castration), or prostate cancer that has been adequately treated with prostatectomy or radiotherapy and currently with no evidence of disease or symptoms and no indication for treatment.
No concomitant anticoagulation with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g., dabigatran), direct factor Xa inhibitor betrixaban, or platelet inhibitors (e.g., clopidogrel).
Allowed anticoagulants are the following:
Prophylactic use of low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH).Therapeutic doses of LMWH or anticoagulation with direct factor Xa inhibitors rivaroxaban, edoxaban, or apixaban in subjects without known brain metastases who are on a stable dose of the anticoagulant for at least 1 week before first dose of study treatment without clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor
Physicians should consider whether any of the following may render the patient inappropriate for this protocol:
Psychiatric illness which would prevent the patient from giving informed consent.

- Uncontrolled medical conditions which, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient.

- Patients who cannot swallow oral formulations of the agent(s).
In addition:
Women and men of reproductive potential should agree to use an appropriate method of birth control throughout their participation in this study due to the teratogenic potential of the therapy utilized in this trial. Include as applicable: Appropriate methods of birth control include abstinence, oral contraceptives, implantable hormonal contraceptives or double barrier method (diaphragm plus condom).

- Patients with rheumatoid arthritis and other rheumatologic arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and or steroids equivalent to < 10 mg prednisone daily, not on immunosuppressive medications and patients with positive serology are eligible. Patients with vitiligo, endocrine deficiencies including hypo or hyper thyroid disease managed with replacement, diabetes type 1 are eligible. - Sexually active subjects (men and women) must agree to use medically accepted barrier methods of contraception (e.g., male or female condom) during the study and continue for 4 months after the last dose of study drugs, even if oral contraceptives are also used.

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Shilpa Gupta

Role: Principal Investigator

Affiliation: Alliance for Clinical Trials in Oncology

Overall Contact

Name: Shilpa Gupta

Phone: N/A

Email: N/A

LOCATION

Facility Status Contact
Facility: Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Canton
Canton, Illinois 61520
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Carthage
Carthage, Illinois 62321
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Facility: Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
United States
Status: Recruiting Contact: Contact
Site Public Contact
815-285-7800
morganthaler.jodi@mhsil.com
Facility: Illinois CancerCare-Dixon
Dixon, Illinois 61021
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
217-876-4762
andersonj@illinoiscancercare.com
Facility: Crossroads Cancer Center
Effingham, Illinois 62401
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Eureka
Eureka, Illinois 61530
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Macomb
Macomb, Illinois 61455
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Pekin
Pekin, Illinois 61554
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Peoria
Peoria, Illinois 61615
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Peru
Peru, Illinois 61354
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com
Facility: Illinois CancerCare-Princeton
Princeton, Illinois 61356
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
217-545-7929
ksoder@mcfarlandclinic.com
Facility: Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Status: Recruiting Contact: Contact
Site Public Contact
309-243-3605
MCRCwebsitecontactform@stjoeshealth.org
Facility: Illinois CancerCare - Washington
Washington, Illinois 61571
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
515-956-4132
MCRCwebsitecontactform@stjoeshealth.org
Facility: Mary Greeley Medical Center
Ames, Iowa 50010
United States
Status: Recruiting Contact: Contact
Site Public Contact
515-239-4734
MCRCwebsitecontactform@stjoeshealth.org
Facility: McFarland Clinic PC - Ames
Ames, Iowa 50010
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
515-956-4132
MCRCwebsitecontactform@stjoeshealth.org
Facility: McFarland Clinic PC-Boone
Boone, Iowa 50036
United States
Status: Recruiting Contact: Contact
Site Public Contact
515-956-4132
MCRCwebsitecontactform@stjoeshealth.org
Facility: McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, Iowa 50501
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
515-956-4132
MCRCwebsitecontactform@stjoeshealth.org
Facility: McFarland Clinic PC-Jefferson
Jefferson, Iowa 50129
United States
Status: Recruiting Contact: Contact
Site Public Contact
515-956-4132
MCRCwebsitecontactform@stjoeshealth.org
Facility: McFarland Clinic PC-Marshalltown
Marshalltown, Iowa 50158
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: IHA Hematology Oncology Consultants-Brighton
Brighton, Michigan 48114
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: Saint Joseph Mercy Brighton
Brighton, Michigan 48114
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
stephanie.couch@stjoeshealth.org
Facility: IHA Hematology Oncology Consultants-Canton
Canton, Michigan 48188
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: Saint Joseph Mercy Canton
Canton, Michigan 48188
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: IHA Hematology Oncology Consultants-Chelsea
Chelsea, Michigan 48118
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: Saint Joseph Mercy Chelsea
Chelsea, Michigan 48118
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org
Facility: Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
OncologyClinicalTrialsFargo@sanfordhealth.org
Facility: Saint Mary Mercy Hospital
Livonia, Michigan 48154
United States
Status: Recruiting Contact: Principal Investigator
Bryan A. Faller
734-712-3671
mmcorc@healthpartners.com
Facility: 21st Century Oncology-Pontiac
Pontiac, Michigan 48341
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
mmcorc@healthpartners.com
Facility: Hope Cancer Center
Pontiac, Michigan 48341
United States
Status: Recruiting Contact: Principal Investigator
Debra M. Prow
734-712-7251
sfmc@sfmc.net
Facility: Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
OncologyClinicalTrialsFargo@sanfordhealth.org
Facility: Saint Joseph Mercy Oakland
Pontiac, Michigan 48341
United States
Status: Recruiting Contact: Principal Investigator
Debra M. Prow
734-712-7251
OncologyClinicalTrialsFargo@sanfordhealth.org
Facility: Huron Gastroenterology PC
Ypsilanti, Michigan 48106
United States
Status: Recruiting Contact: Contact
Site Public Contact
734-712-7251
OncologyClinicalTrialsFargo@sanfordhealth.org
Facility: IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, Michigan 48197
United States
Status: Recruiting Contact: Principal Investigator
Debra M. Prow
218-333-5000
TaussigResearch@ccf.org
Facility: Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
United States
Status: Recruiting Contact: Contact
Site Public Contact
952-993-1517
TaussigResearch@ccf.org
Facility: Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
United States
Status: Recruiting Contact: Principal Investigator
Debra M. Prow
952-993-1517
TaussigResearch@ccf.org
Facility: Regions Hospital
Saint Paul, Minnesota 55101
United States
Status: Recruiting Contact: Contact
Site Public Contact
573-334-2230
TaussigResearch@ccf.org
Facility: Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Status: Recruiting Contact: Principal Investigator
Debra M. Prow
603-224-2556
TaussigResearch@ccf.org
Facility: New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire 03301
United States
Status: Recruiting Contact: Contact
Site Public Contact
800-339-6484
TaussigResearch@ccf.org
Facility: Solinsky Center for Cancer Care
Manchester, New Hampshire 03103
United States
Status: Recruiting Contact: Principal Investigator
Debra M. Prow
212-639-7592
TaussigResearch@ccf.org
Facility: Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Status: Recruiting Contact: Contact
Site Public Contact
701-323-5760
TaussigResearch@ccf.org
Facility: Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
701-323-5760
Kim.Williams3@prismahealth.org
Facility: Sanford Broadway Medical Center
Fargo, North Dakota 58122
United States
Status: Recruiting Contact: Contact
Site Public Contact
701-234-6161
OncologyClinicTrialsSF@sanfordhealth.org
Facility: Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
866-223-8100
OncologyClinicalTrialsSF@SanfordHealth.org
Facility: Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
United States
Status: Recruiting Contact: Contact
Site Public Contact
866-223-8100
Facility: Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
866-223-8100
Facility: Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906
United States
Status: Recruiting Contact: Contact
Site Public Contact
866-223-8100
Facility: Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
866-223-8100
Facility: North Coast Cancer Care
Sandusky, Ohio 44870
United States
Status: Recruiting Contact: Contact
Site Public Contact
866-223-8100
Facility: Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio 44136
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
866-223-8100
Facility: South Pointe Hospital
Warrensville Heights, Ohio 44122
United States
Status: Recruiting Contact: Contact
Site Public Contact
866-223-8100
Facility: Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
864-241-6251
Facility: Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina 29316
United States
Status: Recruiting Contact: Contact
Site Public Contact
864-522-2066
Facility: Prisma Health Cancer Institute - Easley
Easley, South Carolina 29640
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
864-241-6251
Facility: Prisma Health Cancer Institute - Butternut
Greenville, South Carolina 29605
United States
Status: Recruiting Contact: Contact
Site Public Contact
864-241-6251
Facility: Prisma Health Cancer Institute - Faris
Greenville, South Carolina 29605
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
864-241-6251
Facility: Prisma Health Greenville Memorial Hospital
Greenville, South Carolina 29605
United States
Status: Recruiting Contact: Contact
Site Public Contact
864-241-6251
Facility: Prisma Health Cancer Institute - Eastside
Greenville, South Carolina 29615
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
864-241-6251
Facility: Prisma Health Cancer Institute - Greer
Greer, South Carolina 29650
United States
Status: Recruiting Contact: Contact
Site Public Contact
864-241-6251
Facility: Prisma Health Cancer Institute - Seneca
Seneca, South Carolina 29672
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
605-312-3320
Facility: Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United States
Status: Recruiting Contact: Contact
Site Public Contact
605-312-3320
Facility: Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
United States
Status: Recruiting Contact: Principal Investigator
Tareq Al Baghdadi
865-544-9773
Facility: University of Tennessee - Knoxville
Knoxville, Tennessee 37920
United States
Status: Recruiting Contact: Contact
Site Public Contact