Brief Title: A Home-Based Prehabilitation Exercise Intervention for Improving Physical Function in Patients Receiving Chemotherapy Before Radical Cystectomy, Get Moving Trial

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Trial recruitment

Primary Outcome 1 - Timeframe: At enrollment

Primary Outcome 2 - Measure: Trial retention

Primary Outcome 2 - Timeframe: Through study completion

Primary Outcome 3 - Measure: Change in physical function

Primary Outcome 3 - Timeframe: on average 4-7 months

Primary Outcome 4 - Measure: Change in physical function

Primary Outcome 4 - Timeframe: From enrollment (T1) to 1-4 months post enrollment (before surgery) (T2)

Primary Outcome 5 - Measure: Change in physical function

Primary Outcome 5 - Timeframe: From 1-4 months post enrollment (before surgery) (T2) to 4-7 months post enrollment (90 days post surgery) (T3)

CONDITION

• Bladder Cancer
• Urothelial Carcinoma
• Upper Tract Urothelial Carcinoma

ELIGIBILITY

Inclusion Criteria:
* 18 years of age or older

- * English-speaking

- * Planned treatment with radical cystectomy or radical nephroureterectomy/ureterectomy with or without preceding systemic therapy as indicated by the patient's surgeon with enough time to complete a minimum of 4 weeks of exercises before surgery if enrolled in the (P)REHAB arm

- * Willing and able to participate in trial activities
Exclusion Criteria:
* Cognitive/mental impairment that will preclude ability to participate in routine exercise activities. Significant cognitive or memory impairment or baseline dementia that would preclude a patient's ability to follow instructions or reproduce exercises as characterized by scoring < 24 on the Mini-mental Status Assessment - * Immobility, inability/unwillingness to perform personalized exercise program. Inability to perform exercises safely from seated or standing position at home or recent falls or high fall risk. Neurologic or orthopedic condition that restricts participation in unsupervised home exercises, such as prior stroke with neurologic impairment, weight bearing precautions, unwillingness to participate in exercises - * Inability to understand or read English - * Participants who have nonmuscle-invasive urothelial cancer of the bladder/upper tract anticipating undergoing organ-preserving treatments, or radiographic evidence of metastatic disease involving other organs including brain metastases. - * Patients with predominant histology other than urothelial carcinoma of the bladder or upper tracts (e.g. metastasis from another cancer) who would not otherwise be considered candidates for standard definitive or consolidative surgeries (radical cystectomy, ureterectomy, radical nephroureterectomy) with/without treatment with preoperative/neoadjuvant systemic therapy.Uncontrolled or concurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements - * Pregnant women are excluded from this study - * No access to an Android or iOS smart device with the minimum criteria for using ExerciseRx. - * Not receiving surgery at UWMC - * Participation in a clinical trial that does not permit enrollment in the Get Moving trial.

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Sarah Psutka

Role: Principal Investigator

Affiliation: Fred Hutch/University of Washington Cancer Consortium

Overall Contact

Name: Get Moving Research Coordinator

Phone: 206-210-4040

Email: [email protected]

LOCATION