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Brief Title: A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Following Cystectomy

A Phase III, Double-Blind, Multicenter, Randomized Study of Atezolizumab (Anti-PDL1 Antibody) Versus Placebo as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Following Cystectomy

INTRODUCTION

  • Org Study ID: BO42843
  • Secondary ID: N/A
  • NTC ID: NCT04660344
  • Sponsor: Hoffmann-La Roche

BRIEF SUMMARY

This is a global Phase III, randomized, placebo-controlled, double-blind study designed to evaluate the efficacy and safety of adjuvant treatment with atezolizumab compared with placebo in participants with MIBC who are ctDNA positive and are at high risk for recurrence following cystectomy.

  • Overall Status
    Recruiting
  • Start Date
    May 3, 2021
  • Phase
    Phase 3
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Investigator-assessed DFS in Participants Who Are ctDNA Positive Within 24 Weeks of Cystectomy

Primary Outcome 1 - Timeframe: Randomization up to first occurrence of DFS event (up to approximately 73 months)

CONDITION

  • Muscle-invasive Bladder Cancer

ELIGIBILITY

Inclusion Criteria for the Surveillance Phase:
Histologically confirmed MIUC (also termed TCC) of the bladder

- TNM classification (based on AJCC Cancer Staging Manual, 8th Edition; Amin et al. 2016) at pathological examination of surgical resection specimen as follows: For patients treated with prior NAC: tumor stage of ypT2-4a or ypN+ and M0. For patients who have not received prior NAC: tumor stage of pT2-4a or pN+ and M0

- Surgical resection of MIUC of the bladder

- Patients who have not received prior platinum-based NAC, have refused, or are ineligible ("unfit") for cisplatin-based adjuvant chemotherapy. pT2N0 patients who have not received prior platinum-based NAC regardless of cisplatin ineligibility are eligible.

- ctDNA assay developed based on tumor tissue specimen and matched normal DNA from blood.

- Tumor PD-L1 expression per IHC that is evaluable by central testing of a representative tumor tissue specimen.

- Absence of residual disease and absence of metastasis, as confirmed by a negative baseline computed tomography (CT) or magnetic resonance imaging (MRI) scan of the pelvis, abdomen, and chest no more than 4 weeks prior to enrollment.

- Full recovery from cystectomy and enrollment within 24 weeks following cystectomy. Minimum of 6 weeks must have elapsed from surgery.
Additional Inclusion Criteria for the Treatment Phase:
Blood for plasma ctDNA sample evaluated to be ctDNA positive, defined as the presence of two or more mutations out of the 16 mutations identified based on patient's WES evaluable (ctDNA assay designability) report

- Absence of residual disease and absence of metastasis, as confirmed by a negative baseline CT or MRI scan of the pelvis, abdomen, and chest no more than 28 days prior to randomization.

- ECOG Performance Status of <= 2 - Life expectancy >=12 weeks

- Adequate hematologic and end-organ function

- For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use contraception and agreement to refrain from donating eggs
General Medical Exclusion Criteria for the Surveillance Phase:
Known PD-L1 IHC result for adjuvant therapy. The decision for the adjuvant therapy should not be based on the PD-L1 IHC result.

- Pregnancy or breastfeeding

- Positive test for HIV, with the following exception: Patients with a positive HIV test at screening are eligible provided they are stable on antiretroviral therapy, have a CD4 count >= 200/µL, and have an undetectable viral load

- Patients with active hepatitis B virus or hepatitis C. Patients with past HBV infection or resolved HBV infection are eligible. HBV DNA must be obtained in these patients prior to enrollment.
Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA.
Active tuberculosis confirmed by a test performed within 3 months prior to treatment start.

- History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins

- Known hypersensitivity to biopharmaceuticals produced in Chinese hamster ovary cells or any component of the atezolizumab formulation

- History of autoimmune disease. Patients with a history of autoimmune-related hypothyroidism on a stable dose of thyroid replacement hormone may be eligible for this study. Patients with controlled Type I diabetes mellitus on a stable dose of insulin regimen may be eligible for this study.

- History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan. History of radiation pneumonitis in the radiation field (fibrosis) is permitted.

- Significant cardiovascular disease, such as New York Heart Association cardiac disease (Class II or greater), myocardial infarction within the previous 3 months, unstable arrhythmias, or unstable angina
Cancer-Specific Exclusion Criteria for the Surveillance Phase:
Any approved anti-cancer therapy, including chemotherapy, or hormonal therapy within 3 weeks prior to study enrollment

- Adjuvant chemotherapy or radiation therapy for UC following cystectomy

- Treatment with any other investigational agent or participation in another clinical trial with therapeutic intent within 28 days or 5 half-lives of the drug, whichever is longer, prior to enrollment

- Malignancies other than UC within 5 years prior to study enrollment
Additional Exclusion Criteria for the Treatment Phase:
Any approved anti-cancer therapy, including chemotherapy, or hormonal therapy within 3 weeks prior to randomization to the treatment phase Hormone-replacement therapy or oral contraceptives are allowed.

- Adjuvant chemotherapy or radiation therapy for UC following cystectomy

- Treatment with any other investigational agent or participation in another clinical trial with therapeutic intent within 28 days or 5 half-lives of the drug, whichever is longer, prior to randomization to the treatment phase

- Positive test for HIV, with the following exception: Patients with a positive HIV test at screening are eligible provided they are stable on antiretroviral therapy, have a CD4 count >= 200/μL, and have an undetectable viral load.

- Patients with active hepatitis B virus or hepatitis C

- Active tuberculosis confirmed by a test performed within 3 months prior to treatment initiation

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Clinical Trials

Role: Study Director

Affiliation: Hoffmann-La Roche

Overall Contact

Name: Clinical Trials

Phone: 888-662-6728 (U.S. and Canada)

Email: global.rochegenentechtrials@roche.com

LOCATION

Facility Status Contact
Facility: Sansum Clinic
Santa Barbara, California 93105
United States
Status: Recruiting Contact: N/A
Facility: Rocky Mountain Cancer Center - Denver
Littleton, Colorado 80120
United States
Status: Recruiting Contact: N/A
Facility: Woodlands Medical Specialists, P.A.
Pensacola, Florida 32503
United States
Status: Recruiting Contact: N/A
Facility: Cancer Care Centers of Brevard
Rockledge, Florida 32955
United States
Status: Recruiting Contact: N/A
Facility: Optum Health Care
Las Vegas, Nevada 89102
United States
Status: Recruiting Contact: N/A
Facility: Wake Forest Baptist Medical Center
Winston-Salem, North Carolina 27157
United States
Status: Recruiting Contact: N/A
Facility: Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
United States
Status: Recruiting Contact: N/A
Facility: Texas Oncology Cancer Center
Austin, Texas 78731
United States
Status: Recruiting Contact: N/A
Facility: Texas Oncology-Fort Worth 12th Ave
Fort Worth, Texas 76104
United States
Status: Recruiting Contact: N/A
Facility: Centro Medico Austral
Buenos Aires, CE 1019
Argentina
Status: Recruiting Contact: N/A
Facility: Instituto Alexander Fleming
Buenos Aires, CE 1426
Argentina
Status: Recruiting Contact: N/A
Facility: Cemic; Oncologia Clinica
Buenos Aires, MG C1431FWN
Argentina
Status: Recruiting Contact: N/A
Facility: AZ KLINA
Brasschaat, PR 2930
Belgium
Status: Recruiting Contact: N/A
Facility: UZ Gent
Gent, RS 9000
Belgium
Status: Recruiting Contact: N/A
Facility: AZ Delta (Campus Rumbeke)
Roeselare, RS 8800
Belgium
Status: Recruiting Contact: N/A
Facility: Oncocentro Serviços Medicos E Hospitalares Ltda
Fortaleza, RS 60135-237
Brazil
Status: Recruiting Contact: N/A
Facility: Crio - Centro Regional Integrado de Oncologia
Fortaleza, RS 60336-550
Brazil
Status: Recruiting Contact: N/A
Facility: CETUS Hospital Dia Oncologia
Uberaba, SC 38082-049
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital Erasto Gaertner
Curitiba, SP 81520-060
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital Moinhos de Vento
Porto Alegre, SP 90035-000
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital Sao Lucas - PUCRS
Porto Alegre, SP 90610-000
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital Nossa Senhora da Conceicao
Porto Alegre, SP 91350-200
Brazil
Status: Recruiting Contact: N/A
Facility: Clinica Viver
Santa Maria, SP 97015-373
Brazil
Status: Recruiting Contact: N/A
Facility: Centro de Pesquisas Oncologicas - CEPON
Florianopolis, Alberta 88034-000
Brazil
Status: Recruiting Contact: N/A
Facility: *X*Fundação Pio XII Hospital de Câncer de Barretos
Barretos, Ontario 14784-400
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital Amaral Carvalho
Jau, Ontario 17210-120
Brazil
Status: Recruiting Contact: N/A
Facility: Instituto do Cancer do Estado de Sao Paulo - ICESP
Sao Paulo, Ontario 01246-000
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital Alemao Oswaldo Cruz; Pesquisa Clinica
Sao Paulo, Campania 01323-020
Brazil
Status: Recruiting Contact: N/A
Facility: Beneficencia Portuguesa de Sao Paulo
São Paulo, Campania 01321-00
Brazil
Status: Recruiting Contact: N/A
Facility: Cross Cancer Institute
Edmonton, Emilia-Romagna T6G 1Z2
Canada
Status: Recruiting Contact: N/A
Facility: Health Sciences North
Sudbury, Emilia-Romagna P3E 5J1
Canada
Status: Recruiting Contact: N/A
Facility: Sunnybrook Research Institute
Toronto, Lazio M4N 3M5
Canada
Status: Recruiting Contact: N/A
Facility: Princess Margaret Cancer Center
Toronto, Liguria M5G 1Z5
Canada
Status: Recruiting Contact: N/A
Facility: Peking University First Hospital
Beijing City, Lombardia 100034
China
Status: Recruiting Contact: N/A
Facility: Friendship Hospital, Capital Medical University
Beijing, Lombardia 100050
China
Status: Recruiting Contact: N/A
Facility: the First Hospital of Jilin University
Changchun, Piemonte 130021
China
Status: Recruiting Contact: N/A
Facility: Hu Nan Provincial Cancer Hospital
Changsha, Toscana 410006
China
Status: Recruiting Contact: N/A
Facility: Chongqing Cancer Hospital
Chongqing, Umbria 400030
China
Status: Recruiting Contact: N/A
Facility: The First Affiliated Hospital of Fujian Medical University
Fu Zhou, Veneto 350005
China
Status: Recruiting Contact: N/A
Facility: Fujian Medical University Union Hospital
Fuzhou City, Kaluga 350001
China
Status: Recruiting Contact: N/A
Facility: The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Barcelona 510120
China
Status: Recruiting Contact: N/A
Facility: Harbin Medical University Cancer Hospital
Harbin, Cordoba 150081
China
Status: Recruiting Contact: N/A
Facility: Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Nanjing City, Guipuzcoa 210008
China
Status: Recruiting Contact: N/A
Facility: Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University)
Nanjing City, Kharkiv Governorate 210029
China
Status: Recruiting Contact: N/A
Facility: Huashan Hospital Affiliated to Fudan University
Shanghai City, KIEV Governorate 200040
China
Status: Recruiting Contact: N/A
Facility: Fudan University Shanghai Cancer Center
Shanghai City, KIEV Governorate 200120
China
Status: Recruiting Contact: N/A
Facility: Liaoning cancer Hospital & Institute
Shenyang, 110042
China
Status: Recruiting Contact: N/A
Facility: Tianjin Cancer Hospital
Tianjin, 300060
China
Status: Recruiting Contact: N/A
Facility: Xinjiang Medical University Cancer Hospital
Urumqi City, 830011
China
Status: Recruiting Contact: N/A
Facility: Clinica del Country
Bogota, 11001
Colombia
Status: Recruiting Contact: N/A
Facility: Oncomedica S.A.
Monteria, 230002
Colombia
Status: Recruiting Contact: N/A
Facility: Fakultni nemocnice Olomouc; Onkologicka klinika
Olomouc, 779 00
Czechia
Status: Recruiting Contact: N/A
Facility: Thomayerova nemocnice; Onkologicka klinika 1. LF UK A TN
Praha 4 - Krc, 140 59
Czechia
Status: Recruiting Contact: N/A
Facility: Fakultni nemocnice v Motole; Onkologicka klinika 2. LF UK a FN Motol
Praha 5, 150 06
Czechia
Status: Recruiting Contact: N/A
Facility: Institut Sainte Catherine;Recherche Clinique
Avignon, 84918
France
Status: Recruiting Contact: N/A
Facility: Hopital Saint Andre
Bordeaux, 33075
France
Status: Recruiting Contact: N/A
Facility: Centre Jean Perrin
Clermont Ferrand, 63011
France
Status: Recruiting Contact: N/A
Facility: Centre Léon Bérard; Centre régional; le cancer Rhône-Alpes
Lyon, 69373
France
Status: Recruiting Contact: N/A
Facility: Centre D'Oncologie de Gentilly; Oncology
Nancy, 54100
France
Status: Recruiting Contact: N/A
Facility: Centre Antoine Lacassagne
Nice, 06189
France
Status: Recruiting Contact: N/A
Facility: Institut Mutualiste Montsouris; Oncologie
Paris, 75674
France
Status: Recruiting Contact: N/A
Facility: Hopital Foch; Oncologie
Suresnes, 92151
France
Status: Recruiting Contact: N/A
Facility: Institut Claudius Régaud
Toulouse, 31059
France
Status: Recruiting Contact: N/A
Facility: Institut Gustave Roussy; Departement Oncologie Medicale
Villejuif, 94805
France
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Düsseldorf; Urologische Klinik
Düsseldorf, 40225
Germany
Status: Recruiting Contact: N/A
Facility: Krankenhaus Martha-Maria Halle-Dölau, Klinik für Urologie
Halle (Saale), 06120
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum der Ruhr-Universität Bochum, Marien-Hospital Herne, Urologische Klinik
Herne, 44625
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Jena, Urologische Klinik und Poliklinik
Jena, 07743
Germany
Status: Recruiting Contact: N/A
Facility: Klinikum rechts der Isar der TU München; Urologische Klinik und Poliklinik
München, 81675
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Münster, Klinik für Urologie und Kinderurologie
Münster, 48149
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Tübingen; Klinik für Urologie
Tübingen, 72076
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Ulm; Klinik für Urologie
Ulm, 89081
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Würzburg; Klinik und Poliklinik für Urologie und Kinderurologie
Würzburg, 97080
Germany
Status: Recruiting Contact: N/A
Facility: Attikon University General Hospital
Ahens, 124 64
Greece
Status: Recruiting Contact: N/A
Facility: Alexandras General Hospital of Athens; Oncology Department
Athens, 115 28
Greece
Status: Recruiting Contact: N/A
Facility: University Hospital of Larissa;Department of Medical Oncology
Larissa, 411 10
Greece
Status: Recruiting Contact: N/A
Facility: University Hospital of Patras Medical Oncology
Patras, 265 04
Greece
Status: Recruiting Contact: N/A
Facility: Theageneio Hospital
Thessaloniki, 54007
Greece
Status: Recruiting Contact: N/A
Facility: Adelaide & Meath Hospital, Dublin, Incorporating the National Children's Hospital; Oncology Day Unit
Dublin, 24
Ireland
Status: Recruiting Contact: N/A
Facility: St Vincents University Hospital
Dublin, 3109601
Ireland
Status: Recruiting Contact: N/A
Facility: Rambam Medical Center; Oncology
Haifa, 9112000
Israel
Status: Recruiting Contact: N/A
Facility: Hadassah Ein Karem Hospital; Oncology Dept
Jerusalem, 4941492
Israel
Status: Recruiting Contact: N/A
Facility: Tel Aviv Sourasky Medical Ctr; Oncology
Tel Aviv, 80131
Israel
Status: Recruiting Contact: N/A
Facility: Azienda Ospedaliera di Rilievo Nazionale "Antonio Cardarelli", Day Hospital Oncologico
Napoli, 80131
Italy
Status: Recruiting Contact: N/A
Facility: ISTITUTO NAZIONALE TUMORI IRCCS FONDAZIONE G. PASCALE; Dipartimento Uro-Ginecologico
Napoli, 40138
Italy
Status: Recruiting Contact: N/A
Facility: AZ.Osp S. Orsola - Malpighi-Reparto di Oncologia Medica
Bologna, 47014
Italy
Status: Recruiting Contact: N/A
Facility: IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, 00168
Italy
Status: Recruiting Contact: N/A
Facility: Policlinico Universitario "Agostino Gemelli"; U.O.C. Oncologia Medica
Roma, 16132
Italy
Status: Recruiting Contact: N/A
Facility: A.O. Universitaria S. Martino Di Genova
Genova, 20132
Italy
Status: Recruiting Contact: N/A
Facility: Irccs Ospedale San Raffaele
Milano, 20141
Italy
Status: Recruiting Contact: N/A
Facility: Istituto Europeo Di Oncologia
Milano, 10043
Italy
Status: Recruiting Contact: N/A
Facility: A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica
Orbassano, 52100
Italy
Status: Recruiting Contact: N/A
Facility: Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia
Arezzo, 20089
Italy
Status: Recruiting Contact: N/A
Facility: Azienda Ospedaliera Santa Maria di Terni
Terni, 35128
Italy
Status: Recruiting Contact: N/A
Facility: IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II
Padova, 466-8560
Italy
Status: Recruiting Contact: N/A
Facility: Nagoya University Hospital
Aichi, 260-8717
Japan
Status: Recruiting Contact: N/A
Facility: Chiba Cancer Center
Chiba, 285-8741
Japan
Status: Recruiting Contact: N/A
Facility: Toho University Sakura Medical Center
Chiba, 791-0280
Japan
Status: Recruiting Contact: N/A
Facility: Shikoku Cancer Center
Ehime, 812-8582
Japan
Status: Recruiting Contact: N/A
Facility: Kyushu University Hospital
Fukuoka, 721-8511
Japan
Status: Recruiting Contact: N/A
Facility: Fukuyama City Hospital
Hiroshima, 730-8518
Japan
Status: Recruiting Contact: N/A
Facility: Hiroshima City Hiroshima Citizens Hospital
Hiroshima, 003-0804
Japan
Status: Recruiting Contact: N/A
Facility: National Hospital Organization Hokkaido Cancer Center
Hokkaido, 305-8576
Japan
Status: Recruiting Contact: N/A
Facility: University of Tsukuba Hospital
Ibaraki, 028-3695
Japan
Status: Recruiting Contact: N/A
Facility: St. Marianna University Hospital
Kanagawa, 238-8558
Japan
Status: Recruiting Contact: N/A
Facility: Yokosuka Kyosai Hospital
Kanagawa, 606-8507
Japan
Status: Recruiting Contact: N/A
Facility: Kyoto University Hospital
Kyoto, 381-8551
Japan
Status: Recruiting Contact: N/A
Facility: Nagano Municipal Hospital
Nagano, 700-8558
Japan
Status: Recruiting Contact: N/A
Facility: Okayama University Hospital
Okayama, 541-8567
Japan
Status: Recruiting Contact: N/A
Facility: Osaka International Cancer Institute
Osaka, 565-0871
Japan
Status: Recruiting Contact: N/A
Facility: Osaka University Hospital
Osaka, 350-1298
Japan
Status: Recruiting Contact: N/A
Facility: Saitama Medical University International Medical Center
Saitama, 362-0806
Japan
Status: Recruiting Contact: N/A
Facility: Saitama Cancer Center
Saitama, 411-8777
Japan
Status: Recruiting Contact: N/A
Facility: Shizuoka Cancer Center
Shizuoka, 770-8503
Japan
Status: Recruiting Contact: N/A
Facility: Tokushima University Hospital
Tokushima, 104-0045
Japan
Status: Recruiting Contact: N/A
Facility: National Cancer Center Hospital
Tokyo, 135-8550
Japan
Status: Recruiting Contact: N/A
Facility: The Cancer Institute Hospital of JFCR
Tokyo, 160-8582
Japan
Status: Recruiting Contact: N/A
Facility: Keio University Hospital
Tokyo, 930-0194
Japan
Status: Recruiting Contact: N/A
Facility: Toyama University Hospital
Toyama, 41404
Japan
Status: Recruiting Contact: N/A
Facility: Kyungpook National University Chilgok Hospital
Daegu, 10408
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: National Cancer Center
Goyang-si, 03080
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Seoul National University Hospital
Seoul, 05505
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Asan Medical Center
Seoul, 06351
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Samsung Medical Center
Seoul, 36-200
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Szpital Specjalistyczny Podkarpacki Ośrodek Onkologiczny
Brzozów, 85-094
Poland
Status: Recruiting Contact: N/A
Facility: Szpital Uniwersytecki Nr 1 im. Dr. Antoniego Jurasza w Bydgoszczy; Klinika Urologii i Onkologicznej
Bydgoszcz, 30-510
Poland
Status: Recruiting Contact: N/A
Facility: PRATIA MCM Kraków
Kraków, 60-569
Poland
Status: Recruiting Contact: N/A
Facility: Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu; Oddział Chemioterapii
Poznań, 04-073
Poland
Status: Recruiting Contact: N/A
Facility: Szpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o.
Warszawa, 53-413
Poland
Status: Recruiting Contact: N/A
Facility: Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii
Wrocław, 93-513
Poland
Status: Recruiting Contact: N/A
Facility: Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi
Łódź, 249036
Poland
Status: Recruiting Contact: N/A
Facility: Ivanovo Regional Oncology Dispensary
Ivanovo, 188663
Russian Federation
Status: Recruiting Contact: N/A
Facility: St-Petersburg Regional Oncology Dispensary; Oncology
Kuzmolovo, 117997
Russian Federation
Status: Recruiting Contact: N/A
Facility: Privolzhsk Regional Medical Center
Nizhny Novgorod, 197758
Russian Federation
Status: Recruiting Contact: N/A
Facility: FSI Russian Centre of Radiology and Surgical Technologies
Saint-Petersburg, 8208
Russian Federation
Status: Recruiting Contact: N/A
Facility: Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
Sabadell, 14004
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario Reina Sofia; Servicio de Oncologia
Córdoba, 20080
Spain
Status: Recruiting Contact: N/A
Facility: Hospital de Donostia; Servicio de Oncologia Medica
San Sebastian, 08035
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitari Vall d'Hebron; Oncology
Barcelona, 08036
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Clínic i Provincial; Servicio de Oncología
Barcelona, 08041
Spain
Status: Recruiting Contact: N/A
Facility: Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
Barcelona, 28007
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Ramon y Cajal; Servicio de Oncologia
Madrid, 28040
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Clinico San Carlos; Servicio de Oncologia
Madrid, 28041
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario 12 de Octubre; Servicio de Oncologia
Madrid, 28046
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario La Paz; Servicio de Oncologia
Madrid, 41013
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario Virgen del Rocio; Servicio de Oncologia
Sevilla, 46009
Spain
Status: Recruiting Contact: N/A
Facility: Instituto Valenciano Oncologia; Oncologia Medica
Valencia, 01230
Spain
Status: Recruiting Contact: N/A
Facility: Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology
Adana, 06700
Turkey
Status: Recruiting Contact: N/A
Facility: Ankara University Faculty of Medicine Cebeci Hospital
Ankara, 34147
Turkey
Status: Recruiting Contact: N/A
Facility: Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji
Bakirkoy / Istanbul, 22030
Turkey
Status: Recruiting Contact: N/A
Facility: Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
Edirne, 34098
Turkey
Status: Recruiting Contact: N/A
Facility: Istanbul University Cerrahpasa Faculty of Medicine
Istanbul, 34722
Turkey
Status: Recruiting Contact: N/A
Facility: Medeniyet University Goztepe Training and Research Hospital.
Kadiköy, 35575
Turkey
Status: Recruiting Contact: N/A
Facility: Medikal Park Izmir Hospital
Karşıyaka, 55200
Turkey
Status: Recruiting Contact: N/A
Facility: Medikal Park Samsun
Samsun, 61037
Turkey
Status: Recruiting Contact: N/A
Facility: Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval Department of Urology #4
Kharkiv, 49005
Ukraine
Status: Recruiting Contact: N/A
Facility: ME Dnipropetrovsk Regional Clinical Hospital n.a. I.I Mechnykov Dnipropetrovsk Regional Council
Dnipro, 79010
Ukraine
Status: Recruiting Contact: N/A
Facility: Lviv Regional Clinical Hospital
Lviv, 49102
Ukraine
Status: Recruiting Contact: N/A
Facility: CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MR
Dnipropetrovsk, 03115
Ukraine
Status: Recruiting Contact: N/A
Facility: Kyiv City Clinical Oncological Center
Kyiv, BT9 7AB
Ukraine
Status: Recruiting Contact: N/A
Facility: Belfast City Hospital
Belfast, CB2 0QQ
United Kingdom
Status: Recruiting Contact: N/A
Facility: Addenbrookes Hospital
Cambridge, EH4 2XU
United Kingdom
Status: Recruiting Contact: N/A
Facility: Western General Hospital
Edinburgh, EC1M 6BQ
United Kingdom
Status: Recruiting Contact: N/A
Facility: Barts Hospital; Institute of Cancer
London, NW1 2PG
United Kingdom
Status: Recruiting Contact: N/A
Facility: University College London NHS Foundation Trust
London, SW3 6JJ
United Kingdom
Status: Recruiting Contact: N/A
Facility: Royal Marsden Hospital - London
London, W6 8RF
United Kingdom
Status: Recruiting Contact: N/A
Facility: Charing Cross Hospital
London, PL6 8DH
United Kingdom
Status: Recruiting Contact: N/A
Facility: Derriford Hospital
Plymouth, PR2 9HT
United Kingdom
Status: Recruiting Contact: N/A
Facility: Royal Preston Hospital
Preston, S10 2SJ
United Kingdom
Status: Recruiting Contact: N/A
Facility: Weston Park Hospital
Sheffield, SO16 6YD
United Kingdom
Status: Recruiting Contact: N/A
Facility: Southampton University Hospitals NHS Trust
Southampton, SM2 5PT
United Kingdom
Status: Recruiting Contact: N/A
Facility: Royal Marsden Hospital (Sutton)
Sutton,
United Kingdom
Status: Recruiting Contact: N/A