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Brief Title: A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancer

A Study of Intravesical Bacillus Calmette-Guerin (BCG) in Combination With ALT-803 (N-803) in Patients With Non-Muscle Invasive Bladder Cancer

INTRODUCTION

  • Org Study ID: CA-ALT-803-01-14; QUILT-2.005
  • Secondary ID: N/A
  • NTC ID: NCT02138734
  • Sponsor: ImmunityBio, Inc.

BRIEF SUMMARY

This is a Phase Ib/IIb, randomized, two-cohort, open-label, multicenter study of intravesical N-803 plus BCG versus BCG alone, in BCG naïve patients with high-grade NMIBC.

DETAILED DESCRIPTION

The study includes a dose escalation phase (phase Ib) and an expansion phase (phase IIb).

In the phase Ib, patients will be treated with intravesical N-803 in combination with BCG. The purpose of the phase Ib portion of the study is to evaluate the safety, identify the Maximum Tolerated Dose (MTD) of N-803 and determine the Recommended Dose (RD) level of N-803 in combination with BCG for the phase IIb expansion.

In the phase IIb expansion, patients will be randomized to receive either intravesical N-803 in combination with BCG or BCG alone. Patients will be enrolled into one of two study cohorts (Cohort A and Cohort B). These will be two independent study cohorts, evaluated separately for treatment efficacy.

  • Overall Status
    Recruiting
  • Start Date
    July 21, 2014
  • Phase
    Phase 1, Phase 2
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Complete Response (CR) Rate

Primary Outcome 1 - Timeframe: 12 months

Primary Outcome 2 - Measure: Disease Free Survival (DFS)

Primary Outcome 2 - Timeframe: 24 months

CONDITION

  • Non-muscle Invasive Bladder Cancer

ELIGIBILITY

Inclusion Criteria
Histologic confirmation of non-muscle invasive bladder cancer of the transitional cell carcinoma high-grade subtype (mixed histology tumors allowed if transitional cell histology is predominant histology).
Cohort A: Histologically confirmed CIS (with or without Ta/T1 disease); Cohort B: Histologically confirmed high-grade papillary disease (Ta/T1 only).

- Patients are eligible if the diagnostic biopsy was done within 3 months of treatment start and a cystoscopy demonstrating no resectable disease was done within 6 calendar weeks (inclusive of 48 days) of treatment start (residual CIS is acceptable; patients with T1 disease must undergo repeat resection if muscularis propria is not present in each biopsy sample). Patients with high-grade Ta and/or T1 disease should have complete resection before study treatment.

- Upper tract imaging within 6 months prior to study entry must not be suspicious for upper tract malignancy.

- Currently eligible for intravesical BCG therapy.

- Age ≥ 18 years.

- Performance status: ECOG performance status of 0, 1, or 2.
Laboratory tests performed within 21 days of treatment start:
Absolute neutrophil count (AGC/ANC) ≥ 1,000/µL

- Platelets ≥ 100,000/µL [Patients may be transfused to meet this requirement]

- Hemoglobin ≥ 8 g/dL [Patients may be transfused to meet this requirement]

- Calculated glomerular filtration rate (GFR*) >40 mL/min or Serum creatinine ≤ 1.5 x ULN

- Total bilirubin ≤ 2.0 X ULN

- AST, ALT, ALP ≤ 3.0 X ULN

- Adequate pulmonary function without any clinical sign of severe pulmonary dysfunction. PFT > 50% FEV1 if clinically indicated by the investigator.

- Negative serum pregnancy test if female and of childbearing potential (non-childbearing is defined as greater than one year postmenopausal or surgically sterilized).

- Female participants of childbearing potential must adhere to using a medically accepted method of birth control prior to screening and agree to continue its use during the study or be surgically sterilized (e.g., hysterectomy or tubal ligation) and males must agree to use barrier methods of birth control while on study.
Provide signed informed consent and HIPPA authorization and agree to comply with all protocol-specified procedures and follow-up evaluations.
using the following Cockcroft-Gault equation to calculate the eGFR for this study: eGFR in mL/min = {(140-age in years) x (weight in kg) x F}/(serum creatinine in mg/dL x 72) Where F =1 if male; and 0.85 if female
Exclusion Criteria
Prior BCG treatment or known hypersensitivity to BCG. Patients who have received more than a single-dose post-operative treatment of mitomycin-C or gemcitabine following the most recent screening TURBT/biopsy are excluded.

- Concurrent use of other investigational agents (not including FDA-authorized drugs for the prevention and treatment of COVID-19).

- History of or evidence of muscle-invasive, locally advanced, metastatic and/or extravesical bladder cancer or any other cancer within the past 5 years, except: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage 1 or 2 cancer from which the patient is currently in complete remission, or stable prostate cancer (under active surveillance or hormone control).

- Symptomatic congestive heart failure (CHF), NYHA (New York Heart Association) Class III or IV or other clinical signs of severe cardiac dysfunction.

- Severe/unstable angina pectoris, or myocardial infarction within 6 months prior to study entry.

- History or evidence of uncontrollable CNS disease.

- Known HIV-positive.

- Active systemic infection requiring parenteral antibiotic therapy. All prior infections must have resolved following optimal therapy.

- Concurrent febrile illness, active urinary tract infection, active tuberculosis, a history of hypotension or anaphylactic reactions.

- Ongoing chronic systemic steroid therapy required (>10 mg oral prednisone daily or equivalent).

- Women who are pregnant or nursing. Female patients of childbearing potential must have a negative pregnancy test and must adhere to using a medically acceptable method of birth control prior to screening and agree to continue its use during the study and for 30 days after the last dose of study drug, or be surgically sterilized (e.g., hysterectomy or tubal ligation). Women of childbearing potential are defined as any female who has experienced menarche and who is NOT permanently sterile or postmenopausal. Postmenopausal is defined as 12 consecutive months with no menses without an alternative medical cause. Males must agree to use barrier methods of birth control while on study and for 90 days post last dose of study drug.

- Psychiatric illness/social situations that would limit compliance with study requirements.

- Other illness that in the opinion of the investigator would exclude the patient from participating in this study.

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Bobby Reddy, MD

Role: Study Director

Affiliation: ImmunityBio, Inc.

Overall Contact

Name: Bobby Reddy, MD

Phone: 844-413-8500, 9499038749

Email: paula.bradshaw@immunitybio.com, atessa.kiani@immunitybio.com

LOCATION

Facility Status Contact
Facility: Hoag Cancer Center
Irvine, California 92618
United States
Status: Recruiting Contact: Contact
Sara Rodriguez
919-537-3505
Austin.Lannon@moffitt.org
Facility: UCLA Department of Urology
Los Angeles, California 90095
United States
Status: Recruiting Contact: Principal Investigator
Karim Chamie, MD

quinn.p.coughlin@hitchcock.org
Facility: Moffitt Cancer Center
Tampa, Florida 33612
United States
Status: Recruiting Contact: Principal Investigator
Aaron E Katz, MD

Facility: Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire 03756
United States
Status: Recruiting Contact: Principal Investigator
Marc Bjurlin, DO

Facility: Winthrop University Hospital
Mineola, New York 11501
United States
Status: Recruiting Contact: Principal Investigator
Mark Jalkut, MD

Facility: Manhattan Medical Research
New York, New York 10016
United States
Status: Recruiting Contact: Contact
Brittany Quigley

Facility: Premier Medical Group of the Hudson Valley
Poughkeepsie, New York 12601
United States
Status: Recruiting Contact: Principal Investigator
Eugene Kramolowsky, MD

Facility: University of North Carolina Chapel Hill
Chapel Hill, North Carolina 27278
United States
Status: Recruiting Contact: N/A
Facility: Associated Urologists of North Carolina
Raleigh, North Carolina 27612
United States
Status: Recruiting Contact: N/A
Facility: Virginia Urology
Richmond, Virginia 23235
United States
Status: Recruiting Contact: N/A