English Español
Back to Clinical Trials

Brief Title: A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder

A Phase 3, Multi-center, Randomized Study Evaluating Efficacy of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-Invasive Urothelial Carcinoma (MIBC) of the Bladder Who Are Not Receiving Radical Cystectomy

INTRODUCTION

  • Org Study ID: CR108917
  • Secondary ID: 2020-002620-36, 17000139BLC3001
  • NTC ID: NCT04658862
  • Sponsor: Janssen Research & Development, LLC

BRIEF SUMMARY

The purpose of study is to compare bladder intact-event free survival (BI-EFS) in participants receiving TAR-200 in combination with intravenous (IV) cetrelimab versus concurrent chemoradiotherapy.

DETAILED DESCRIPTION

The TAR-200 is an investigational intravesical drug delivery system. Cetrelimab (JNJ-63723283) is a fully human immunoglobulin G4 (IgG4) kappa monoclonal antibody (mAb) that binds programmed cell death protein 1 (PD-1). Study consists of screening phase of 42 days, treatment phase and follow up phase. The total duration of study will be up to 8 years. Efficacy evaluation includes disease assessment (Cystoscopy/TURBT Biopsy/Pathology) and Patient Reported Outcomes (Quality of Life Assessments) and safety assessments includes vital sign measurements, 12-lead electrocardiogram (ECG), physical examinations, clinical laboratory tests, cystoscopic examination, anti-drug antibody (ADA) assessments, concomitant treatments/procedures and adverse event monitoring.

  • Overall Status
    Recruiting
  • Start Date
    December 7, 2020
  • Phase
    Phase 3
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Time from Randomization to the First Bladder Intact Event-free Survival (BI-EFS) event

Primary Outcome 1 - Timeframe: Up to 8 years

CONDITION

  • Urinary Bladder Neoplasms

ELIGIBILITY

Inclusion Criteria:
Ineligible for or have elected not to undergo radical cystectomy

- All adverse events associated with any prior surgery and/or intravesical therapy must have resolved to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 Grade less than (<) 2 prior to randomization - Eastern Cooperative Oncology Group (ECOG) performance status Grade 0, 1, or 2 - Thyroid function tests within normal range or stable on hormone supplementation per investigator assessment. Investigators may consult an endocrinologist for participant eligibility assessment in the case of equivocal or marginal test results. - Adequate bone marrow, liver, and renal function: Bone marrow function (without the support of cytokines or erythropoiesis-stimulating agent in preceding two weeks): Absolute neutrophil count (ANC) greater than or equal to (>=) 1,500/cubic millimeters (mm^3); Platelet count >=80,000/mm^3; Hemoglobin >=9.0 grams per deciliter (g/dL); Liver function: (Total bilirubin less than or equal to (<=) 1.5 * upper limit of normal (ULN) or direct bilirubin <= ULN for participants with total bilirubin levels greater than (>)1.5*ULN (except participants with Gilbert's Syndrome, who must have a total bilirubin < 3.0 mg/dL), and Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) less than or equal to (<=) 2.5* institutional ULN); Renal function: Creatinine clearance >30 mL/min using the Cockcroft-Gault formula.
Exclusion Criteria:
Must not have had urothelial carcinoma or histological variant at any site outside of the urinary bladder. Ta/T1/Carcinoma in situ (CIS) of the upper urinary tract (including renal pelvis and ureter) is allowable if treated with complete nephroureterectomy more than 24 months prior to initiating study

- Must not have diffuse CIS based on cystoscopy and biopsy. Diffuse, or multi-focal, CIS is defined as the presence of at least 4 distinct CIS lesions in the bladder at the time of the Screening re-TURBT

- Participants must not have evidence of cT4b, or N1-3, or M1 disease based on local radiology staging (chest, abdomen, and pelvis must be performed using Computed tomography [CT] or Magnetic resonance imaging [MRI]) within 42 days prior to randomization

- Presence of any bladder or urethral anatomic feature that, in the opinion of the investigator, may prevent the safe placement, indwelling use, or removal of TAR 200

- Evidence of bladder perforation during diagnostic cystoscopy

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Janssen Research & Development, LLC Clinical Trials

Role: Study Director

Affiliation: Janssen Research & Development, LLC

Overall Contact

Name: Janssen Research & Development, LLC Clinical Trials

Phone: 844-434-4210

Email: Participate-In-This-Study@its.jnj.com

LOCATION

Facility Status Contact
Facility: University of Southern California
Los Angeles, California 90033
United States
Status: Recruiting Contact: N/A
Facility: The Urology Center of Colorado
Denver, Colorado 80211
United States
Status: Recruiting Contact: N/A
Facility: Foothills Urology - Golden Off
Golden, Colorado 80401
United States
Status: Recruiting Contact: N/A
Facility: Winship Cancer Institute of Emory University
Atlanta, Georgia 30322
United States
Status: Recruiting Contact: N/A
Facility: DuPage Medical Group
Lisle, Illinois 60532
United States
Status: Recruiting Contact: N/A
Facility: Duke University Medical Center
Durham, North Carolina 27710
United States
Status: Recruiting Contact: N/A
Facility: Vidant Urology - Greenville
Greenville, North Carolina 27834
United States
Status: Recruiting Contact: N/A
Facility: Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer Center
Winston-Salem, North Carolina 27103
United States
Status: Recruiting Contact: N/A
Facility: Stephenson Cancer Center
Oklahoma City, Oklahoma 73104
United States
Status: Recruiting Contact: N/A
Facility: MidLantic Urology
Bala-Cynwyd, Pennsylvania 19004
United States
Status: Recruiting Contact: N/A
Facility: Carolina Urologic Research Center
Myrtle Beach, South Carolina 29572
United States
Status: Recruiting Contact: N/A
Facility: University of Texas Medical Branch
League City, Texas 77573
United States
Status: Recruiting Contact: N/A
Facility: Virginia Oncology Associates
Norfolk, Virginia 23502
United States
Status: Recruiting Contact: N/A
Facility: Fundacion Intecnus
Bariloche, British Columbia 8400
Argentina
Status: Recruiting Contact: N/A
Facility: Sociedade Beneficente de Senhoras - Hospital Sírio Libanês
Buenos Aires, British Columbia C1419AHN
Argentina
Status: Recruiting Contact: N/A
Facility: Instituto Medico Especializado Alexander Fleming
Buenos Aires, Ontario C1426ANZ
Argentina
Status: Recruiting Contact: N/A
Facility: Hospital Italiano de Buenos Aires
Ciudad Autónoma De Buenos Aires, Ontario C1199ABB
Argentina
Status: Recruiting Contact: N/A
Facility: Cemaic - Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica
Córdoba, Ontario 5000
Argentina
Status: Recruiting Contact: N/A
Facility: Centro Urologico Profesor Bengio
Córdoba, Quebec X5000KPH
Argentina
Status: Recruiting Contact: N/A
Facility: Sanatorio Allende Cerro
Córdoba, Quebec X5004FHP
Argentina
Status: Recruiting Contact: N/A
Facility: Centro Oncologico Riojano Integral (Cori)
La Rioja, Quebec F5300COE
Argentina
Status: Recruiting Contact: N/A
Facility: Centro de Investigacion Pergamino SA
Pergamino, B2700CPM
Argentina
Status: Recruiting Contact: N/A
Facility: CEDIC Centro de Investigaciones Clinicas
Viedma, R8500EYO
Argentina
Status: Recruiting Contact: N/A
Facility: Flinders Medical Centre
Bedford Park, 5042
Australia
Status: Recruiting Contact: N/A
Facility: Krankenhaus der barmherzigen Schwestern
Linz, 4010
Austria
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Salzburg - Landeskrankenhaus
Salzburg, 5020
Austria
Status: Recruiting Contact: N/A
Facility: Hopital Erasme
Anderlecht, 1070
Belgium
Status: Recruiting Contact: N/A
Facility: ZNA Middelheim
Antwerpen, 2020
Belgium
Status: Recruiting Contact: N/A
Facility: AZ Sint-Lucas
Assebroek, 8310
Belgium
Status: Recruiting Contact: N/A
Facility: AZ Sint-Jan Brugge-Oostende AV
Brugge, 8000
Belgium
Status: Recruiting Contact: N/A
Facility: Az Groeninge
Kortrijk, 8500
Belgium
Status: Recruiting Contact: N/A
Facility: Fundacao Pio XII
Barretos, 14784-400
Brazil
Status: Recruiting Contact: N/A
Facility: Fundação Hospitalar São Francisco de Assis
Belo Horizonte, 31110-580
Brazil
Status: Recruiting Contact: N/A
Facility: Liga Paranaense de Combate ao Cancer
Curitiba, 81520-060
Brazil
Status: Recruiting Contact: N/A
Facility: Centro Regional Integrado de Oncologia - CRIO
Fortaleza, 60336-232
Brazil
Status: Recruiting Contact: N/A
Facility: Clinica de Oncologia Reichow
Jardim Blumenau, 89010-340
Brazil
Status: Recruiting Contact: N/A
Facility: Fundacao Doutor Amaral Carvalho
Jau, 17210-080
Brazil
Status: Recruiting Contact: N/A
Facility: Liga Norte Riograndense Contra O Cancer
Natal, 59062-000
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital das Clinicas de Porto Alegre
Porto Alegre, 90035-903
Brazil
Status: Recruiting Contact: N/A
Facility: União Brasileira de Educação e Assistência-Hospital São Lucas da PUCRS
Porto Alegre, 90610-000
Brazil
Status: Recruiting Contact: N/A
Facility: Hospital Sao Rafael
Salvador, 41253-190
Brazil
Status: Recruiting Contact: N/A
Facility: CEPHO - Centro de Estudos e Pesquisa de Hematologia e Oncologia
Santo André, 09060-650
Brazil
Status: Recruiting Contact: N/A
Facility: Fundação Faculdade Regional de Medicina de São José do Rio Preto - Hospital de Base
Sao Jose do Rio Preto, 15090-000
Brazil
Status: Recruiting Contact: N/A
Facility: Instituto de Assistencia Medica ao Servidor Publico Estadual - IAMSPE
Sao Paulo, 04039-004
Brazil
Status: Recruiting Contact: N/A
Facility: Sociedade Beneficente de Senhoras - Hospital Sirio Libanes
Sao Paulo, 04784180
Brazil
Status: Recruiting Contact: N/A
Facility: Centro Oncológico do Triângulo
Uberlândia, 38408-150
Brazil
Status: Recruiting Contact: N/A
Facility: Chinese Academy of Medical Sciences(CAMS) & Peking Union Medical College(PUMC)
Beijing, 100021
China
Status: Recruiting Contact: N/A
Facility: Peking University First Hospital
Beijing, 100034
China
Status: Recruiting Contact: N/A
Facility: The First Hospital of Jilin University
Changchun, 130021
China
Status: Recruiting Contact: N/A
Facility: The Third Xiangya Hospital of Central Sourth University
Changsha, 410013
China
Status: Recruiting Contact: N/A
Facility: West China Hospital of Sichuan University
Chengdu, 610041
China
Status: Recruiting Contact: N/A
Facility: Chongqing University Cancer Hospital
Chongqing, 400030
China
Status: Recruiting Contact: N/A
Facility: Guangzhou First Municipal People's Hospital
Guang Zhou Shi, 510180
China
Status: Recruiting Contact: N/A
Facility: Sun Yat-Sen University Cancer Center
Guangzhou, 510060
China
Status: Recruiting Contact: N/A
Facility: Zhejiang Provincial People's Hospital
Hangzhou, 310014
China
Status: Recruiting Contact: N/A
Facility: The First Hospital of Jiaxing
Jiaxing, 11026101-1
China
Status: Recruiting Contact: N/A
Facility: Nanjing Drum Tower Hospital
Nanjing, 210008
China
Status: Recruiting Contact: N/A
Facility: Qingdao Municipal Hospital
Qingdao, 266011
China
Status: Recruiting Contact: N/A
Facility: Renji Hospital
Shanghai, 200020
China
Status: Recruiting Contact: N/A
Facility: Shengjing Hospital of China Medical University
Shenyang, 110004
China
Status: Recruiting Contact: N/A
Facility: The First Affiliated Hospital of Wenzhou Medical University
Wenzhou Shi, 325000
China
Status: Recruiting Contact: N/A
Facility: Wuhan Union Hospital
Wuhan, 430023
China
Status: Recruiting Contact: N/A
Facility: Wuhan Tongji Hospital, Tongji Medical College
Wuhan, 430030
China
Status: Recruiting Contact: N/A
Facility: Yantai Yuhuangding Hospital
Yantai, 264000
China
Status: Recruiting Contact: N/A
Facility: Henan Cancer Hospital
Zhengzhou, 450008
China
Status: Recruiting Contact: N/A
Facility: Slezska nemocnice v Opave
Opava, 746 01
Czechia
Status: Recruiting Contact: N/A
Facility: Fakultni nemocnice Plze
Plzen-Bory, 305 99
Czechia
Status: Recruiting Contact: N/A
Facility: Thomayerova nemocnice
Praha 4, 140 59
Czechia
Status: Recruiting Contact: N/A
Facility: Fakultni nemocnice v Motole
Praha 5, 150 06
Czechia
Status: Recruiting Contact: N/A
Facility: Nemocnice Na Bulovce
Praha 8, 180 81
Czechia
Status: Recruiting Contact: N/A
Facility: Fakultni nemocnice Kralovske Vinohrady
Praha, 100 34
Czechia
Status: Recruiting Contact: N/A
Facility: Clinique Sainte Marguerite
Hyeres, 83400
France
Status: Recruiting Contact: N/A
Facility: Polyclinique de Limoges - Francois Chenieux
Limoges, 87000
France
Status: Recruiting Contact: N/A
Facility: Hôpital Edouard Herriot
Lyon Cedex 03, 69437
France
Status: Recruiting Contact: N/A
Facility: Institut Paoli-Calmettes
Marseille, 13009
France
Status: Recruiting Contact: N/A
Facility: Institut Regional du Cancer de Montpellier
Montpellier, 34298
France
Status: Recruiting Contact: N/A
Facility: CHU Nîmes
Nimes, 30029
France
Status: Recruiting Contact: N/A
Facility: Hopital Europeen Georges-Pompidou
Paris, 75015
France
Status: Recruiting Contact: N/A
Facility: Hôpital Bichat - Claude Bernard
Paris, 75018
France
Status: Recruiting Contact: N/A
Facility: Centre Hospitalier Prive
Saint-Grégoire, 35760
France
Status: Recruiting Contact: N/A
Facility: Hopital Foch
Suresnes, 92150
France
Status: Recruiting Contact: N/A
Facility: Urologicum Duisburg
Duisburg, 47179
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Düsseldorf
Düesseldorf, 40225
Germany
Status: Recruiting Contact: N/A
Facility: Agaplesion Frankfurter Diakonie Kliniken GmbH, Markus Krankenhaus
Frankfurt Am Main, 60431
Germany
Status: Recruiting Contact: N/A
Facility: Universitatsklinikum Frankfurt
Frankfurt am Main, 60590
Germany
Status: Recruiting Contact: N/A
Facility: Klinikum Herne - Urologie
Herne, 44625
Germany
Status: Recruiting Contact: N/A
Facility: Matthias Schulze - Germany
Markkleeberg, 04416
Germany
Status: Recruiting Contact: N/A
Facility: Universitätsklinikum Münster
Münster, 48149
Germany
Status: Recruiting Contact: N/A
Facility: Klinikum Nürnberg Nord - Hautklinik
Nürnberg, 90419
Germany
Status: Recruiting Contact: N/A
Facility: Alexandra General Hospital of Athens
Athens, 11528
Greece
Status: Recruiting Contact: N/A
Facility: Metropolitan General A.E.
Holargos, 155 62
Greece
Status: Recruiting Contact: N/A
Facility: Athens Medical Center
Maroussi, 151 25
Greece
Status: Recruiting Contact: N/A
Facility: Metropolitan Hospital
Neo Faliro, 18547
Greece
Status: Recruiting Contact: N/A
Facility: Bioclinic - Thessaloniki
Thessaloniki, 546 22
Greece
Status: Recruiting Contact: N/A
Facility: Euromedica General Clinic
Thessaloniki, 54645
Greece
Status: Recruiting Contact: N/A
Facility: 'Papageorgiou' General Hospital of Thessaloniki
Thessaloniki, TK 56403
Greece
Status: Recruiting Contact: N/A
Facility: Anassa General Clinic
Volos, 38333
Greece
Status: Recruiting Contact: N/A
Facility: Orszagos Onkologiai Intezet
Budapest N/a, 1122
Hungary
Status: Recruiting Contact: N/A
Facility: Bajcsy-Zsilinszky Kórház és Rendelőintézet
Budapest, 1106
Hungary
Status: Recruiting Contact: N/A
Facility: Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032
Hungary
Status: Recruiting Contact: N/A
Facility: Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz
Nyíregyháza, 4400
Hungary
Status: Recruiting Contact: N/A
Facility: Sujan Surgical Cancer Hospital & Amravati Cancer Foundation
Amravati, 400601
India
Status: Recruiting Contact: N/A
Facility: Acharya Tulsi Regional Cancer Treatment Research Institute
Bikaner, 334 003
India
Status: Recruiting Contact: N/A
Facility: Shatabdi Super Speciality Hospital
Nashik, 422005
India
Status: Recruiting Contact: N/A
Facility: BLK Super Specialty Hospital
New Delhi, 110005
India
Status: Recruiting Contact: N/A
Facility: Rajiv Gandhi Cancer Institute & Research Centre
New Delhi, 110085
India
Status: Recruiting Contact: N/A
Facility: Indira Gandhi Institute of Medical Sciences
Patna, 800014
India
Status: Recruiting Contact: N/A
Facility: Jehangir Clinical Development Center Pvt Ltd
Pune, 411001
India
Status: Recruiting Contact: N/A
Facility: Fondazione del Piemonte per I'Oncologia IRCC Candiolo
Candiolo, 10060
Italy
Status: Recruiting Contact: N/A
Facility: SPDC Villa Scassi
Genova, 16100
Italy
Status: Recruiting Contact: N/A
Facility: Ospedale San Martino
Genova, 16132
Italy
Status: Recruiting Contact: N/A
Facility: Istituto Europeo di Oncologia
Milano, 20141
Italy
Status: Recruiting Contact: N/A
Facility: Ospedale San Raffaele
Milan, 20132
Italy
Status: Recruiting Contact: N/A
Facility: Azienda Sanitaria Locale Salerno - Po Andrea Tortora Di Pagani
Pagani, 84016
Italy
Status: Recruiting Contact: N/A
Facility: Azienda Ospedaliero Universitaria Pisana
Pisa, 56126
Italy
Status: Recruiting Contact: N/A
Facility: ASL Napoli 2 Nord-SM delle Grazie Hospital
Pozzuoli, 80078
Italy
Status: Recruiting Contact: N/A
Facility: Policlinico Universitario Agostino Gemelli
Roma, 00168
Italy
Status: Recruiting Contact: N/A
Facility: Azienda Ospedaliera Sant Andrea
Roma, 00189
Italy
Status: Recruiting Contact: N/A
Facility: Istituto Nazionale Tumori Regina Elena
Rome, 00144
Italy
Status: Recruiting Contact: N/A
Facility: Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino
Torino, 10126
Italy
Status: Recruiting Contact: N/A
Facility: Ospedale di Circolo e Fondazione Macchi
Varese, 21100
Italy
Status: Recruiting Contact: N/A
Facility: Ospedale San Bortolo
Vicenza, 36100
Italy
Status: Recruiting Contact: N/A
Facility: Aso Co.,Ltd Iizuka Hospital
Iizuka, 820-8501
Japan
Status: Recruiting Contact: N/A
Facility: St.Marianna University Hospital
Kanagawa, 216-8511
Japan
Status: Recruiting Contact: N/A
Facility: Nara Medical University Hospital
Kashihara, 634-8522
Japan
Status: Recruiting Contact: N/A
Facility: Saitama Medical University Hospital
Kawagoe-Shi, 350-8550
Japan
Status: Recruiting Contact: N/A
Facility: Kimitsu Chuo Hospital
Kisarazu-shi, 292-8535
Japan
Status: Recruiting Contact: N/A
Facility: Nagasaki University Hospital
Nagasaki-shi, 852-8501
Japan
Status: Recruiting Contact: N/A
Facility: JOHAS Osaka Rosai Hospital
Osaka, 591-8025
Japan
Status: Recruiting Contact: N/A
Facility: Tokuyama Central Hospital
Shunan, 745-8522
Japan
Status: Recruiting Contact: N/A
Facility: Toranomon Hospital
Tokyo, 105-8470
Japan
Status: Recruiting Contact: N/A
Facility: Fujita Health University Hospital
Toyoake, 470-1192
Japan
Status: Recruiting Contact: N/A
Facility: Yamaguchi University Hospital
Ube, 755-8505
Japan
Status: Recruiting Contact: N/A
Facility: Yokohama City University Medical Center
Yokohama, 232-0024
Japan
Status: Recruiting Contact: N/A
Facility: Inje University Haeundae Paik Hospital
Busan, 612-896
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Kyungpook National University Chilgok Hospital
Daegu, 41404
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Keimyung University Dongsan Hospital
Daegu, 42601
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: National Cancer Center
Goyang-si, 10408
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Gachon University Gil Medical Center
Namdong, 405 760
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Seoul National University Hospital
Seoul, 03080
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Severance Hospital
Seoul, 03722
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Gangnam Severance Hospital
Seoul, 06273
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 06591
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Pusan National University Yangsan Hospital
Yangsan-si, 50612
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Oncologia Integral Satelite
Ciudad de México, 06720
Mexico
Status: Recruiting Contact: N/A
Facility: Consultorio Privado Dr Jose Arturo Rodriguez Rivera
Guadalajara, 45050
Mexico
Status: Recruiting Contact: N/A
Facility: Centro De Estudio Y Prevencion Del Cancer
Juchitan De Zaragoza, 70000
Mexico
Status: Recruiting Contact: N/A
Facility: Dr. Marco Antonio Badillo Santoyo
Leon, 37000
Mexico
Status: Recruiting Contact: N/A
Facility: i Can Oncology Center
Monterrey, 64710
Mexico
Status: Recruiting Contact: N/A
Facility: Centro de Investigacion Clinica Chapultepec
Morelia, 58260
Mexico
Status: Recruiting Contact: N/A
Facility: Oncológico Potosino
San Luis Potosi, 78250
Mexico
Status: Recruiting Contact: N/A
Facility: Investigación Biomedica para el desarrollo de Farmacos, S.A. de C.V.
Zapopan, 45070
Mexico
Status: Recruiting Contact: N/A
Facility: Centrum Medyczne Pratia Poznan
Skorzewo, 60-185
Poland
Status: Recruiting Contact: N/A
Facility: Centralny Szpital Kliniczny MSWiA w Warszawie
Warszawa, 02-507
Poland
Status: Recruiting Contact: N/A
Facility: Uniwersytecki Szpital Kliniczny
Wroclaw, 50556
Poland
Status: Recruiting Contact: N/A
Facility: Centro Hospitalar e Universitario de Coimbra
Coimbra, 3000075
Portugal
Status: Recruiting Contact: N/A
Facility: H. Santa Maria - Centro Hospitalar de Lisboa Norte
Lisboa, 1649-035
Portugal
Status: Recruiting Contact: N/A
Facility: Fundação Champalimaud
Lisbon, 1400-038
Portugal
Status: Recruiting Contact: N/A
Facility: Hospital de Sao Joao
Porto, 4200-319
Portugal
Status: Recruiting Contact: N/A
Facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, 807
Taiwan
Status: Recruiting Contact: N/A
Facility: China Medical University Hospital
Taichung, 40447
Taiwan
Status: Recruiting Contact: N/A
Facility: Taichung Veterans General Hospital
Taichung, 407
Taiwan
Status: Recruiting Contact: N/A
Facility: National Cheng Kung University Hospital
Tainan, 70403
Taiwan
Status: Recruiting Contact: N/A
Facility: National Taiwan University Hospital
Taipei City, 10048
Taiwan
Status: Recruiting Contact: N/A
Facility: Tri-Service General Hospital
Taipei, 11490
Taiwan
Status: Recruiting Contact: N/A
Facility: Chang Gung Memorial Hospital Linkou Branch
Taoyuan, 333
Taiwan
Status: Recruiting Contact: N/A