Brief Title: Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer

PRIMARY OUTCOMES

Primary Outcome 1 - Measure:

Primary Outcome 1 - Timeframe: N/A

CONDITION

• Localized Renal Pelvis and Ureter Urothelial Carcinoma
• Malignant Solid Neoplasm
• Metastatic Malignant Neoplasm in the Bone
• Metastatic Malignant Neoplasm in the Soft Tissues
• Metastatic Renal Pelvis and Ureter Urothelial Carcinoma
• Recurrent Bladder Carcinoma
• Recurrent Prostate Carcinoma
• Recurrent Renal Pelvis and Ureter Urothelial Carcinoma
• Stage IV Bladder Cancer AJCC v7
• Stage IV Bladder Urothelial Carcinoma AJCC v7
• Stage IV Prostate Cancer AJCC v7

ELIGIBILITY

Inclusion Criteria:
* Patients with localized and/or metastatic bladder/urothelial or prostate cancer who have disease in the primary organ, biopsy accessible bone metastases (collaborating radiologists will determine if bone metastasis is appropriate for biopsy) or soft tissue metastases are eligible; men and women without cancer are eligible to have blood or normal tissue collected if acquired as part of non-research procedures (e.g. transurethral resection of the prostate or bladder); in patients without malignancy, no additional tissue beyond that necessary for care will be procured

- * Ability to adequately understand and give informed consent

- * Local or metastatic disease to soft tissue or bone at sites accessible to biopsy with minimal risk of complications Or the ability to obtain tissue with minimal risk of complication from a surgical procedure being conducted as a part of another research study Or for standard of care purposes or patients who have archival tissue collected for research or standard of care who are willing to donate archival tissue for this study

- * Alternatively, men and women without cancer or who are at risk of developing cancer are eligible to have blood or normal tissue collected if acquired; tissue will only be acquired as part of non-research procedures (e.g. transurethral resection of the prostate or bladder; in patients without malignancy, no additional tissue beyond that necessary for care will be procured

- * Platelet count > 50,000

- * White blood cell (WBC) > 1,500

- * Hemoglobin (Hgb) > 8.0

- * International normalized ratio (INR) < 1.5 - * Partial thromboplastin time (PTT) < 45 - * No history of excessive unexplained bleeding from previous surgery
Exclusion Criteria:
* Patients unable to stop chronic anticoagulation with warfarin or Lovenox for less than 3 days

- * Serious or uncontrolled infection

- * Treatment with a vascular endothelial growth factor (VEGF) inhibitor (such as Avastin) within the past 28 days

Gender: Male

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Robert B. Montgomery

Role: Principal Investigator

Affiliation: Fred Hutch/University of Washington Cancer Consortium

Overall Contact

Name: Robert B. Montgomery

Phone: 206-598-0856

Email: rbmontgo@uw.edu

LOCATION