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Brief Title: Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)

A Phase 3, Randomized, Double-blind Study to Evaluate Perioperative Pembrolizumab (MK-3475) + Neoadjuvant Chemotherapy Versus Perioperative Placebo + Neoadjuvant Chemotherapy in Cisplatin-eligible Participants With Muscle-invasive Bladder Cancer (KEYNOTE-866)

INTRODUCTION

  • Org Study ID: 3475-866
  • Secondary ID: MK-3475-866, KEYNOTE-866, 194870, 2018-003808-39
  • NTC ID: NCT03924856
  • Sponsor: Merck Sharp & Dohme LLC
Merck Oncology Clinical Trials Information

BRIEF SUMMARY

A global study to evaluate peri-operative pembrolizumab with chemotherapy versus placebo to pembrolizumab plus chemotherapy in cisplatin eligible patients.

  • Overall Status
    Recruiting
  • Start Date
    June 13, 2019
  • Phase
    Phase 3
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Pathologic Complete Response (pCR) Rate

Primary Outcome 1 - Timeframe: Up to approximately 15 Weeks (Time of surgery)

Primary Outcome 2 - Measure: Event-Free Survival (EFS)

Primary Outcome 2 - Timeframe: Up to approximately 71 months

CONDITION

  • Urinary Bladder Cancer
  • Muscle-invasive

ELIGIBILITY

Inclusion Criteria:
Have a histologically confirmed diagnosis of urothelial carcinoma (UC) / muscle invasive bladder cancer (MIBC) (T2-T4aN0M0 or T1-T4aN1M0) with predominant (≥50%) urothelial histology

- Have clinically non-metastatic bladder cancer (N≤1 M0) determined by imaging (computed tomography (CT) or magnetic resonance imaging (MRI) of the chest/abdomen/pelvis

- Be deemed eligible for Radical Cystectomy (RC) + Pelvic Lymph Node Dissection (PLND)

- Have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

- Have adequate organ function

- Male and female participants are eligible to participate if they agree to the contraception use as per study protocol
Exclusion Criteria:
Has a known additional malignancy that is progressing or has required active anti-cancer treatment ≤3 years of study randomization with certain exceptions

- Has received any prior systemic treatment for MIBC or non-invasive muscle bladder cancer (NMIBC - prior treatment for NMIBC with intravesical BCG/chemotherapy is permitted) or prior therapy with an anti- programmed cell death 1 (PD-1), anti-programmed cell death ligand 1/ ligand 2 (PD-L1/L2), or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)

- Has ≥N2 disease or metastatic disease (M1) as identified by imaging

- Is cisplatin-ineligible, as defined by meeting any one of the cisplatin ineligibility criteria as per protocol

- Has received prior systemic anticancer therapy including investigational agents within 3 years of randomization or any radiotherapy to the bladder

- Has undergone partial cystectomy of the bladder to remove any NMIBC or MIBC

- Has received a live or live attenuated vaccine within 30 days before the first dose of study intervention

- Has a diagnosis of immunodeficiency or has a known history of human immunodeficiency virus (HIV) infection, Hepatitis B infection or known active Hepatitis C infection

- Has a known psychiatric or substance abuse disorder

- Has had an allogenic tissue/solid organ transplant

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Medical Director

Role: Study Director

Affiliation: Merck Sharp & Dohme LLC

Overall Contact

Name: Medical Director

Phone: 1-888-577-8839

Email: Trialsites@merck.com

LOCATION

Facility Status Contact
Facility: Scripps MD Anderson ( Site 0010)
La Jolla, California 92037
United States
Status: Recruiting Contact: Contact
Study Coordinator
858-554-8367
Facility: Providence Saint John's Health Center ( Site 0075)
Santa Monica, California 90404
United States
Status: Recruiting Contact: Contact
Study Coordinator
310-582-7456
Facility: Indiana University Melvin and Bren Simon Cancer Center ( Site 0004)
Indianapolis, Indiana 46202
United States
Status: Recruiting Contact: Contact
Study Coordinator
314-251-7061
Facility: Ochsner Medical Center ( Site 0049)
New Orleans, Louisiana 70121
United States
Status: Recruiting Contact: Contact
Study Coordinator
973-971-5373
Facility: UMass Memorial Medical Center ( Site 0051)
Worcester, Massachusetts 01655
United States
Status: Recruiting Contact: Contact
Study Coordinator
216-844-6031
Facility: Mercy Hospital Saint Louis ( Site 0064)
Saint Louis, Missouri 63141
United States
Status: Recruiting Contact: Contact
Study Coordinator
412-359-8373
Facility: Morristown Medical Center ( Site 0015)
Morristown, New Jersey 07960-6136
United States
Status: Recruiting Contact: Contact
Study Coordinator
713-563-1602
Facility: New York University Perlmutter Cancer Center ( Site 0008)
New York, New York 10016
United States
Status: Recruiting Contact: Contact
Study Coordinator
206-606-7486
Facility: University Hospitals Cleveland Medical Center ( Site 0038)
Cleveland, Ohio 44106
United States
Status: Recruiting Contact: Contact
Study Coordinator
+61265814053
Facility: Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0021)
Tulsa, Oklahoma 74146
United States
Status: Recruiting Contact: Contact
Study Coordinator
+61397848520
Facility: Allegheny General Hospital ( Site 0048)
Pittsburgh, Pennsylvania 15212
United States
Status: Recruiting Contact: Contact
Study Coordinator
+3211309960
Facility: MD Anderson Cancer Center ( Site 0063)
Houston, Texas 77030
United States
Status: Recruiting Contact: Contact
Study Coordinator
+3281422111
Facility: Northwest Medical Specialties, PLLC ( Site 0061)
Puyallup, Washington 98373
United States
Status: Recruiting Contact: Contact
Study Coordinator
4034762543
Facility: Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0033)
Seattle, Washington 98109
United States
Status: Recruiting Contact: Contact
Study Coordinator
6135496666
Facility: Mid North Coast Cancer Institute ( Site 1256)
Port Macquarie, New South Wales 2444
Australia
Status: Recruiting Contact: Contact
Study Coordinator
4164804928
Facility: Peninsula Health Frankston Hospital ( Site 1258)
Frankston, Victoria 3199
Australia
Status: Recruiting Contact: Contact
Study Coordinator
+45 38683868
Facility: UZ Brussel ( Site 0358)
Brussels, Bruxelles-Capitale, Region De 1090
Belgium
Status: Recruiting Contact: Contact
Study Coordinator
+4524998173
Facility: Jessa Ziekenhuis ( Site 0360)
Hasselt, Limburg 3500
Belgium
Status: Recruiting Contact: Contact
Study Coordinator
+33478782828
Facility: CHU UCL Namur Site de Godinne ( Site 0354)
Yvoir, Namur 5530
Belgium
Status: Recruiting Contact: Contact
Study Coordinator
+33231455002
Facility: O.L.V. Ziekenhuis Aalst ( Site 0356)
Aalst, Oost-Vlaanderen 9300
Belgium
Status: Recruiting Contact: Contact
Study Coordinator
+33296752216
Facility: AZ Maria Middelares Gent ( Site 0353)
Gent, Oost-Vlaanderen 9000
Belgium
Status: Recruiting Contact: Contact
Study Coordinator
+0033146251979
Facility: Tom Baker Cancer Centre ( Site 0100)
Calgary, Alberta T2N 4N2
Canada
Status: Recruiting Contact: Contact
Study Coordinator
+33467336733
Facility: Kingston Health Sciences Centre ( Site 0103)
Kingston, Ontario K7L 2V7
Canada
Status: Recruiting Contact: Contact
Study Coordinator
+33357841590
Facility: Lakeridge Health ( Site 0104)
Oshawa, Ontario L1G 2B9
Canada
Status: Recruiting Contact: Contact
Study Coordinator
+33473278117
Facility: Sunnybrook Research Institute ( Site 0110)
Toronto, Ontario M4N 3M5
Canada
Status: Recruiting Contact: Contact
Study Coordinator
+33243479493
Facility: Princess Margaret Cancer Centre ( Site 0107)
Toronto, Ontario M5G 2M9
Canada
Status: Recruiting Contact: Contact
Study Coordinator
+33232888990
Facility: CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0105)
Montreal, Quebec H1T 2M4
Canada
Status: Recruiting Contact: Contact
Study Coordinator
+33490276090
Facility: CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0111)
Quebec, Hovedstaden G1R 2J6
Canada
Status: Recruiting Contact: Contact
Study Coordinator
+4970712987235
Facility: Herlev og Gentofte Hospital. ( Site 0402)
Herlev, Hovedstaden 2730
Denmark
Status: Recruiting Contact: Contact
Study Coordinator
+4991318333122
Facility: Odense Universitetshospital ( Site 0403)
Odense, Aquitaine 5000
Denmark
Status: Recruiting Contact: Contact
Study Coordinator
+493514582157
Facility: Centre Leon Berard ( Site 0465)
Lyon, Calvados 69373
France
Status: Recruiting Contact: Contact
Study Coordinator
+4930450515288
Facility: Centre Francois Baclesse ( Site 0459)
Caen, Cotes-d Armor 14076
France
Status: Recruiting Contact: Contact
Study Coordinator
+4930130226303
Facility: Centre Armoricain de Radiotherapie Imagerie medicale et Oncologie ( Site 0457)
Plerin, Hauts-de-Seine 22190
France
Status: Recruiting Contact: Contact
Study Coordinator
+3672536480
Facility: Hopital Foch ( Site 0483)
Suresnes, Languedoc-Roussillon 92150
France
Status: Recruiting Contact: Contact
Study Coordinator
+3662545405
Facility: CHU de Montpellier - Hopital Saint-Eloi ( Site 0469)
Montpellier, Maine-et-Loire 34295
France
Status: Recruiting Contact: Contact
Study Coordinator
+3656503603
Facility: Institut de Cancerologie de l Ouest Site Paul Papin ( Site 0453)
Angers, Moselle 49055
France
Status: Recruiting Contact: Contact
Study Coordinator
+3614327500
Facility: Hopital Robert Schuman ( Site 0452)
Metz, Puy-de-Dome 57070
France
Status: Recruiting Contact: Contact
Study Coordinator
+3652255585
Facility: Centre Jean Perrin ( Site 0460)
Clermont-Ferrand, Sarthe 63011
France
Status: Recruiting Contact: Contact
Study Coordinator
+3696507900
Facility: Clinique Victor Hugo ( Site 0463)
Le Mans, Seine-Maritime 72000
France
Status: Recruiting Contact: Contact
Study Coordinator
+353214920052
Facility: CHU de Rouen ( Site 0493)
Rouen, Vaucluse 76031
France
Status: Recruiting Contact: Contact
Study Coordinator
+35314144259
Facility: Institut Sainte Catherine ( Site 0454)
Avignon, Baden-Wurttemberg 84000
France
Status: Recruiting Contact: Contact
Study Coordinator
+97246495723
Facility: Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0502)
Tuebingen, Bayern 72076
Germany
Status: Recruiting Contact: Contact
Study Coordinator
+972523514527
Facility: Universitaetsklinikum Erlangen ( Site 0505)
Erlangen, Sachsen-Anhalt 91058
Germany
Status: Recruiting Contact: Contact
Study Coordinator
+97247776750
Facility: Universitaetsklinikum Magdeburg A.o.R. ( Site 0516)
Magdeburg, Sachsen 39120
Germany
Status: Recruiting Contact: Contact
Study Coordinator
+97226666331
Facility: Universitaetsklinikum Carl Gustav Carus ( Site 0519)
Dresden, Schleswig-Holstein 01307
Germany
Status: Recruiting Contact: Contact
Study Coordinator
+972505172315
Facility: Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0512)
Luebeck, Baranya 23538
Germany
Status: Recruiting Contact: Contact
Study Coordinator
+97297471606
Facility: Charite Universitaetsmedizin Berlin ( Site 0515)
Berlin, Csongrad 10117
Germany
Status: Recruiting Contact: Contact
Study Coordinator
+97239378074
Facility: Vivantes Klinikum am Urban ( Site 0522)
Berlin, Jasz-Nagykun-Szolnok 10967
Germany
Status: Recruiting Contact: Contact
Study Coordinator
+97235302191
Facility: Pecsi Tudomanyegyetem AOK ( Site 1009)
Pecs, Abruzzo 7624
Hungary
Status: Recruiting Contact: Contact
Study Coordinator
+97236973413
Facility: SZTE Szent-Gyorgyi Albert Klinikai Kozpont ( Site 1010)
Szeged, Aomori 6720
Hungary
Status: Recruiting Contact: Contact
Study Coordinator
+97289779715
Facility: Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1002)
Szolnok, Chiba 5004
Hungary
Status: Recruiting Contact: Contact
Study Coordinator
+390630154953
Facility: Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 1001)
Budapest, Ehime 1106
Hungary
Status: Recruiting Contact: Contact
Study Coordinator
+390953781518
Facility: Debreceni Egyetem Klinikai Kozpont ( Site 1006)
Debrecen, Hokkaido 4032
Hungary
Status: Recruiting Contact: Contact
Study Coordinator
+390223902402
Facility: Petz Aladar Megyei Oktato Korhaz ( Site 1012)
Gyor, Ibaraki 9023
Hungary
Status: Recruiting Contact: Contact
Study Coordinator
+390594222648
Facility: Cork University Hospital ( Site 0722)
Cork, Nara T12 DC4A
Ireland
Status: Recruiting Contact: Contact
Study Coordinator
+390658704356
Facility: Tallaght University Hospital ( Site 0710)
Dublin, Saitama D24 DH74
Ireland
Status: Recruiting Contact: Contact
Study Coordinator
+390744205410
Facility: Ha Emek Medical Center ( Site 0808)
Afula, Kyonggi-do 1834111
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+82317877351
Facility: Soroka Medical Center ( Site 0806)
Beer Sheva, Nuevo Leon 8410101
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+8229206610
Facility: Rambam Health Care Campus-Oncology Division ( Site 0802)
Haifa, Dolnoslaskie 3109601
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+82220720361
Facility: Shaare Zedek Medical Center ( Site 0809)
Jerusalem, Kujawsko-pomorskie 9103102
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+82230103980
Facility: Hadassah Ein Kerem Medical Center ( Site 0810)
Jerusalem, Mazowieckie 9112001
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+82234103557
Facility: Meir Medical Center ( Site 0803)
Kfar Saba, Mazowieckie 4428164
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+52818631717
Facility: Rabin Medical Center ( Site 0804)
Petach Tikva, Slaskie 4941492
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+524494735100
Facility: Sheba Medical Center ( Site 0801)
Ramat Gan, Baskortostan, Respublika 5265601
Israel
Status: Recruiting Contact: Contact
Study Coordinator
52 614 410 4214
Facility: Sourasky Medical Center ( Site 0807)
Tel Aviv, Ivanovskaya Oblast 6423906
Israel
Status: Recruiting Contact: Contact
Study Coordinator
+525555734772
Facility: Yitzhak Shamir Medical Center ( Site 0805)
Zerifin, Krasnoyarskiy Kray 7030001
Israel
Status: Recruiting Contact: Contact
Study Coordinator
0048601143281
Facility: Policlinico Gemelli di Roma ( Site 0558)
Roma, Kurskaya Oblast 00168
Italy
Status: Recruiting Contact: Contact
Study Coordinator
+48501446778
Facility: A.O.U. Policlinico Vittorio Emanuele - Presidio Gaspare Rodolico ( Site 0559)
Catania, Moskva 95123
Italy
Status: Recruiting Contact: Contact
Study Coordinator
+48601200599
Facility: Istituto Nazionale Studio e Cura dei Tumori ( Site 0551)
Milano, Moskva 20133
Italy
Status: Recruiting Contact: Contact
Study Coordinator
+48691666578
Facility: Policlinico di Modena ( Site 0553)
Modena, Murmanskaya Oblast 41124
Italy
Status: Recruiting Contact: Contact
Study Coordinator
0048606399091
Facility: Istituto Nazionale Per Lo Studio E La Cura Dei Tumori ( Site 0552)
Napoli, Nizhegorodskaya Oblast 80131
Italy
Status: Recruiting Contact: Contact
Study Coordinator
+34927256200
Facility: Azienda Ospedaliera San Camillo Forlanini ( Site 0560)
Roma, Sankt-Peterburg 00152
Italy
Status: Recruiting Contact: Contact
Study Coordinator
+34913368263
Facility: Azienda Ospedaliera Santa Maria Terni ( Site 0557)
Terni, Sankt-Peterburg 05100
Italy
Status: Recruiting Contact: Contact
Study Coordinator
+34914521987
Facility: National Cancer Center ( Site 1354)
Goyang-si, Kharkivska Oblast 13620
Korea, Republic of
Status: Recruiting Contact: Contact
Study Coordinator
+903322236000
Facility: Seoul National University Bundang Hospital ( Site 1356)
Seongnam-si, Kharkivska Oblast 02841
Korea, Republic of
Status: Recruiting Contact: Contact
Study Coordinator
+905054785576
Facility: Korea University Anam Hospital ( Site 1351)
Seoul, Kyivska Oblast 03080
Korea, Republic of
Status: Recruiting Contact: Contact
Study Coordinator
+905052292035
Facility: Seoul National University Hospital ( Site 1352)
Seoul, Kyivska Oblast 05505
Korea, Republic of
Status: Recruiting Contact: Contact
Study Coordinator
234324432
Facility: Asan Medical Center ( Site 1355)
Seoul, Lvivska Oblast 06351
Korea, Republic of
Status: Recruiting Contact: Contact
Study Coordinator
+4401803655376
Facility: Samsung Medical Center ( Site 1353)
Seoul, Lvivska Oblast 66269
Korea, Republic of
Status: Recruiting Contact: Contact
Study Coordinator
+441227766877
Facility: Centro de Urologia Avanzada del Noreste S.A. de C.V. ( Site 0254)
Monterrey, Aberdeen City 20010
Mexico
Status: Recruiting Contact: Contact
Study Coordinator
+441438284298
Facility: Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V. ( Site 0300)
Aguascalientes, Devon 31000
Mexico
Status: Recruiting Contact: Contact
Study Coordinator
+4402078082911
Facility: Centro Estatal de Cancerologia de Chihuahua ( Site 0253)
Chihuahua, England 14080
Mexico
Status: Recruiting Contact: Contact
Study Coordinator
+442033117627
Facility: Instituto Nacional de Cancerologia ( Site 0256)
Tlalpan, Hertfordshire 50-556
Mexico
Status: Recruiting Contact: Contact
Study Coordinator
+441603287226
Facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 1062)
Wroclaw, London, City Of 85-796
Poland
Status: Recruiting Contact: Contact
Study Coordinator
441872250000
Facility: Centrum Onkologii im.prof. F. Lukaszczyka w Bydgoszczy ( Site 1068)
Bydgoszcz, London, City Of 05-400
Poland
Status: Recruiting Contact: N/A
Facility: Europejskie Centrum Zdrowia Otwock ( Site 1057)
Otwock, Norfolk 01-748
Poland
Status: Recruiting Contact: N/A
Facility: Luxmed Onkologia sp. z o. o. ( Site 1051)
Warszawa, 43-300
Poland
Status: Recruiting Contact: N/A
Facility: Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1060)
Bielsko-Biala, 450081
Poland
Status: Recruiting Contact: N/A
Facility: Hospital San Pedro de Alcantara ( Site 0654)
Caceres, 17007
Spain
Status: Recruiting Contact: N/A
Facility: H. de Gerona Dr. Josep Trueta ( Site 0651)
Girona, 28034
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario Ramon y Cajal ( Site 0660)
Madrid, 28223
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario Quiron Madrid ( Site 0657)
Pozuelo de Alarcon, 46009
Spain
Status: Recruiting Contact: N/A
Facility: Instituto Valenciano de Oncologia - IVO ( Site 0662)
Valencia, 08003
Spain
Status: Recruiting Contact: N/A
Facility: Hospital del Mar ( Site 0653)
Barcelona, 28040
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario San Carlos ( Site 0663)
Madrid, 28046
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario La Paz ( Site 0661)
Madrid, 41014
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Nuestra Sra. de Valme ( Site 0658)
Sevilla, 551 85
Spain
Status: Recruiting Contact: N/A
Facility: Laenssjukhuset Ryhov ( Site 1205)
Jonkoping, 751 85
Sweden
Status: Recruiting Contact: N/A
Facility: Akademiska Sjukhuset ( Site 1201)
Uppsala, 901 85
Sweden
Status: Recruiting Contact: N/A
Facility: Cancercentrum ( Site 1204)
Umea, 10400
Sweden
Status: Recruiting Contact: N/A
Facility: Ramathibodi Hospital. ( Site 1451)
Bangkok, 10700
Thailand
Status: Recruiting Contact: N/A
Facility: Maharaj Nakorn Chiangmai Hospital ( Site 1453)
Chiang Mai, 40002
Thailand
Status: Recruiting Contact: N/A
Facility: Srinagarind Hospital ( Site 1454)
Khon Kaen, 06100
Thailand
Status: Recruiting Contact: N/A
Facility: Hacettepe Universitesi Tıp Fakultesi ( Site 0911)
Ankara, 34096
Turkey
Status: Recruiting Contact: N/A
Facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0910)
Istanbul, 34722
Turkey
Status: Recruiting Contact: N/A
Facility: TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0906)
Istanbul, 34899
Turkey
Status: Recruiting Contact: N/A
Facility: Universitesi Pendik Egitim ve Arastirma Hastanesi ( Site 0901)
Istanbul, 42080
Turkey
Status: Recruiting Contact: N/A
Facility: Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0909)
Konya, 54290
Turkey
Status: Recruiting Contact: N/A
Facility: Sakarya Universitesi Tip Fakultesi ( Site 0913)
Sakarya, 61080
Turkey
Status: Recruiting Contact: N/A
Facility: Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi ( Site 0904)
Trabzon, 18009
Turkey
Status: Recruiting Contact: N/A
Facility: Aberdeen Royal Infirmary ( Site 0708)
Aberdeen, TQ2 7AA
United Kingdom
Status: Recruiting Contact: N/A
Facility: Torbay Hospital ( Site 0704)
Torquay, CT1 3NG
United Kingdom
Status: Recruiting Contact: N/A
Facility: Kent and Canterbury Hospital ( Site 0709)
Canterbury, SG1 4AB
United Kingdom
Status: Recruiting Contact: N/A
Facility: Lister Hospital ( Site 0715)
Stevenage, SW3 6JJ
United Kingdom
Status: Recruiting Contact: N/A
Facility: The Royal Marsden Foundation Trust ( Site 0702)
London, W6 8RF
United Kingdom
Status: Recruiting Contact: N/A
Facility: Imperial College Healthcare NHS Trust ( Site 0721)
London, NR4 7UY
United Kingdom
Status: Recruiting Contact: N/A
Facility: Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 0725)
Norwich, TR1 3LJ
United Kingdom
Status: Recruiting Contact: N/A
Facility: Royal Cornwall Hospital ( Site 0703)
Truro,
United Kingdom
Status: Recruiting Contact: N/A