Brief Title: Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)

PRIMARY OUTCOMES

Primary Outcome 1 - Measure:

Primary Outcome 1 - Timeframe: N/A

CONDITION

• Bladder Cancer
• Non-muscle-invasive Bladder Cancer
• Muscle-Invasive Bladder Carcinoma

ELIGIBILITY

Inclusion Criteria:
* Provision of signed and dated informed consent form

- * Stated willingness to comply with all study procedures and availability for the duration of the study

- * Male or female, aged ≥18 years of age

- * Good surgical candidate determined by treating surgeon

- * Histologically documented muscle invasive urothelial carcinoma of the bladder, high-risk non-muscle invasive bladder cancer, non-muscle invasive bladder cancer refractory to BCG, cisplatin ineligible muscle invasive bladder cancer receiving upfront cystectomy, urothelial carcinoma of the bladder with variant histology

- * Adequate Organ Function per protocol definition

- * ECOG performance status ≤2

- * Received medical clearance to complete cardiopulmonary exercise testing

- * Willing to use the personal or study provided devices for monitoring and performing the exercise routines.

- * Fluent in English or Spanish for the EORTC QLQ questionnaire

- * No known contraindications to high intensity exercise
Exclusion Criteria:
* Contraindications to participating in aerobic exercise

- * Currently participating in an aerobic exercise program

- * New onset chest pain nor dyspnea with exertion

- * Histologically documented micropapillary or sarcomatoid bladder cancer

- * Distant metastatic carcinoma

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: N/A

Role: N/A

Affiliation: N/A

Overall Contact

Name: Christine Ibilibor, Ashley Byrne

Phone: 4349240871, 4349240871

Email: ci5d@virginia.edu, aeb6q@uvahealth.org

LOCATION