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Brief Title: Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming With Intradermal BCG Before Intravesical Therapy for BCG-Naive High-Grade Non-muscle Invasive Bladder Cancer

S1602, A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming With Intradermal BCG Before Intravesical Therapy for BCG-Naive High-Grade Non-muscle Invasive Bladder Cancer

INTRODUCTION

  • Org Study ID: S1602
  • Secondary ID: NCI-2016-00451, S1602, S1602, U10CA180888
  • NCT ID: NCT03091660
  • Sponsor: Southwest Oncology Group

BRIEF SUMMARY


This randomized phase III trial studies Tokyo-172 strain bacillus Calmette-Guerin (BCG)
solution with or without a vaccination using Tokyo-172 strain BCG to see how well it works
compared with TICE BCG solution in treating patients with bladder cancer that has not spread
to muscle. BCG is a non-infectious bacteria that when instilled into the bladder may
stimulate the immune system to fight bladder cancer. Giving different versions of BCG with
vaccine therapy may prevent bladder cancer from returning.

DETAILED DESCRIPTION


PRIMARY OBJECTIVES:

I. To compare whether time to high grade recurrence (TTHGR) for patients with BCG-naïve,
non-muscle invasive bladder cancer (NMIBC) receiving Tokyo-172 BCG strain (Arm II) is
non-inferior to patients receiving TICE BCG strain (Arm I).

II. To test whether TTHGR for patients with BCG-naïve, NMIBC receiving intradermal Tokyo-172
BCG vaccination followed by intravesical Tokyo-172 BCG instillation (Arm III) is superior to
patients receiving intravesical Tokyo-172BCG instillation without prior intradermal BCG
vaccination (Arm II).

SECONDARY OBJECTIVES:

I. To compare time to recurrence (TTR) with any-grade (AG) bladder cancer between patients
receiving Tokyo-172 versus TICE BCG strain.

II. To compare TTR with AG bladder cancer between patients receiving intradermal +
intravesical versus intravesical only Tokyo-172 BCG.

III. To compare progression-free survival (PFS) between patients receiving Tokyo-172 versus
TICE BCG strain.

IV. To compare PFS between patients receiving intradermal + intravesical versus intravesical
only Tokyo-172 BCG.

V. To compare 6-month complete response in patients with carcinoma in situ (CIS) with or
without Ta or T1 cancer present at baseline receiving Tokyo-172 versus TICE BCG strain.

VI. To compare 6-month complete response in patients with CIS with or without Ta or T1 cancer
present at baseline receiving intradermal + intravesical versus intravesical only Tokyo-172
BCG.

TERTIARY OBJECTIVES:

I. To test the hypothesis that purified protein derivative (PPD) test conversion (positive
PPD at 3 or 6 months) following BCG immunotherapy will predict time to high grade recurrence
(TTHGR).

II. To test the hypothesis that urinary cytokine levels following BCG immunotherapy will
predict time to high grade recurrence (TTHGR).

III. To test the hypothesis that tumor neoantigen burden and T lymphocyte infiltration are
associated with BCG response.

OUTLINE: Patients are randomized to 1 of 3 treatment arms.

ARM I:

INDUCTION: Patients receive TICE BCG solution intravesically once a week for 6 weeks.

MAINTENANCE: Patients receive TICE BCG solution once a week for 3 consecutive weeks at months
3, 6, 12, 18, 24, 30, and 36 for up to 7 doses.

ARM II:

INDUCTION: Patients receive Tokyo-172 strain BCG solution intravesically once a week for 6
weeks.

MAINTENANCE: Patients receive Tokyo-172 strain BCG solution once a week for 3 consecutive
weeks at months 3, 6, 12, 18, 24, 30, and 36 for up to 7 doses.

ARM III:

PRIME: Patients receive Tokyo-172 strain BCG vaccine once intradermally (ID).

INDUCTION: Within 21 days, patients receive Tokyo-172 strain BCG solution as in Arm II.

MAINTENANCE: Patients receive Tokyo-172 strain BCG solution as in Arm II.

After completion of study treatment, patients are followed up for 5 years.


  • Overall Status
    Recruiting
  • Start Date
    February 7, 2017
  • Phase
    Phase 3
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: TTHGR for Arm I compared to Arm II

Primary Outcome 1 - Timeframe: Time from randomization to first high grade recurrence assessed up to 5 years

Primary Outcome 2 - Measure: TTHGR for Arm II compared to Arm III

Primary Outcome 2 - Timeframe: Time from randomization to first high grade recurrence assessed up to 5 years

CONDITION

  • Stage 0 Bladder Urothelial Carcinoma
  • Stage 0is Bladder Urothelial Carcinoma
  • Stage I Bladder Urothelial Carcinoma

ELIGIBILITY


Inclusion Criteria:

- Patients must have histologically proven Ta, carcinoma in situ (CIS) or T1 stage
urothelial cell carcinoma of the bladder within 90 days of registration

- Patients must have had all grossly visible papillary tumors removed within 30 days
prior to registration or cystoscopy confirming no grossly visible papillary tumors
within 30 days prior to registration

- Patients with T1 disease must have cross-sectional imaging of abdomen/pelvis
demonstrating no evidence of metastatic disease (magnetic resonance imaging [MRI] or
computed tomography [CT] scan) within 90 days prior to registration; patients with T1
disease must have re-resection confirming =< T1 disease within 90 days prior to
registration

- Patients must have high-grade bladder cancer as defined by 2004 World Health
Organization (WHO)/International Society of Urological Pathology (ISUP) classification

- Patients must not have pure squamous cell carcinoma or adenocarcinoma

- Patients' disease must not have micropapillary components

- Patients must have no evidence of upper tract (renal pelvis or ureters) cancer
confirmed by one of the following tests performed within 90 days prior to
registration: CT urogram, intravenous pyelogram, magnetic resonance (MR) urogram, or
retrograde pyelograms

- Patients must not have nodal involvement or metastatic disease

- No other prior malignancy is allowed except for the following: adequately treated
basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
stage I or II cancer from which the patient is currently in complete remission, or any
other cancer from which the patient has been disease free for five years; patients
with localized prostate cancer who are being followed by an active surveillance
program are also eligible

- Patients must have a Zubrod performance status of 0-2

- Patients must not have received prior intravesical BCG

- Patients must not have known history of tuberculosis

- Patients must be PPD negative within 90 days prior to registration; PPD negativity is
defined as < 10 mm diameter induration (palpable, raised hardened area) in the volar
forearm at 48-72 hours following injection with standard tuberculin dose (5 units, 0.1
ml)

- Patients must be >= 18 years of age

- Patients must not be taking oral glucocorticoids at the time of registration

- Patients must not be planning to receive concomitant biologic therapy, hormonal
therapy, chemotherapy, surgery, or other cancer therapy while on study

- Prestudy history and physical must be obtained within 90days prior to registration

- Patients must not be pregnant or nursing; women/men of reproductive potential must
have agreed to use an effective contraceptive method; a woman is considered to be of
"reproductive potential" if she has had menses at any time in the preceding 12
consecutive months; in addition to routine contraceptive methods, "effective
contraception" also includes heterosexual celibacy and surgery intended to prevent
pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy,
bilateral oophorectomy or bilateral tubal ligation; however, if at any point a
previously celibate patient chooses to become heterosexually active during the time
period for use of contraceptive measures outlined in the protocol, he/she is
responsible for beginning contraceptive measures

- Patients must be offered the opportunity to participate in specimen banking for future
studies to include translational medicine studies

Gender: All

Minimum Age: N/A

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Robert Svatek

Role: Principal Investigator

Affiliation: Southwest Oncology Group

Overall Contact

Name: Robert Svatek

Phone: (210)614-8808

Email: vgarcia@swog.org

LOCATION

Facility Status Contact
Facility: University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688
United States
Status: Recruiting Contact: Site Public Contact
251-445-9870
pfrancisco@usouthal.edu

Facility: Banner MD Anderson Cancer Center
Gilbert, Arizona 85234
United States
Status: Recruiting Contact: Site Public Contact
602-747-9738

Facility: Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
United States
Status: Recruiting Contact: Site Public Contact
855-776-0015

Facility: Mayo Clinic in Arizona
Scottsdale, Arizona 85259
United States
Status: Recruiting Contact: Site Public Contact
855-776-0015

Facility: Los Angeles County-USC Medical Center
Los Angeles, California 90033
United States
Status: Recruiting Contact: Site Public Contact
323-865-0451

Facility: USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
United States
Status: Recruiting Contact: Site Public Contact
323-865-0451

Facility: Cedars Sinai Medical Center
Los Angeles, California 90048
United States
Status: Recruiting Contact: Site Public Contact
310-423-8965

Facility: Kaiser Permanente-Oakland
Oakland, California 94611
United States
Status: Recruiting Contact: Site Public Contact
877-642-4691
Kpoct@kp.org

Facility: UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
United States
Status: Recruiting Contact: Site Public Contact
877-827-8839
ucstudy@uci.edu

Facility: Kaiser Permanente-South Sacramento
Sacramento, California 95823
United States
Status: Recruiting Contact: Site Public Contact
877-642-4691
Kpoct@kp.org

Facility: UCSF Medical Center-Mission Bay
San Francisco, California 94158
United States
Status: Recruiting Contact: Site Public Contact
877-827-3222

Facility: Kaiser Permanente-Vallejo
Vallejo, California 94589
United States
Status: Recruiting Contact: Site Public Contact
877-642-4691
Kpoct@kp.org

Facility: Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
United States
Status: Recruiting Contact: Site Public Contact
877-642-4691
Kpoct@kp.org

Facility: University of Colorado Hospital
Aurora, Colorado 80045
United States
Status: Recruiting Contact: Site Public Contact
720-848-0650

Facility: Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut 06510
United States
Status: Recruiting Contact: Site Public Contact
203-785-5702
canceranswers@yale.edu

Facility: Yale University
New Haven, Connecticut 06520
United States
Status: Recruiting Contact: Site Public Contact
203-785-5702
canceranswers@yale.edu

Facility: MedStar Washington Hospital Center
Washington, District of Columbia 20010
United States
Status: Recruiting Contact: Site Public Contact
202-877-8839

Facility: George Washington University Medical Center
Washington, District of Columbia 20037
United States
Status: Recruiting Contact: Site Public Contact
202-741-2981

Facility: University of Florida Health Science Center - Gainesville
Gainesville, Florida 32610
United States
Status: Recruiting Contact: Site Public Contact
352-273-8010
cancer-center@ufl.edu

Facility: Moffitt Cancer Center - McKinley Campus
Tampa, Florida 33612
United States
Status: Recruiting Contact: Site Public Contact
800-679-0775
canceranswers@moffitt.org

Facility: Moffitt Cancer Center
Tampa, Florida 33612
United States
Status: Recruiting Contact: Site Public Contact
800-679-0775
canceranswers@moffitt.org

Facility: Atlanta VA Medical Center
Decatur, Georgia 30033
United States
Status: Recruiting Contact: Site Public Contact
404-321-6111

Facility: Hawaii Cancer Care - Savio
'Aiea, Hawaii 96701
United States
Status: Recruiting Contact: Site Public Contact
808-539-2273

Facility: Pali Momi Medical Center
'Aiea, Hawaii 96701
United States
Status: Recruiting Contact: Site Public Contact
808-486-6000

Facility: Queen's Cancer Center - Pearlridge
'Aiea, Hawaii 96701
United States
Status: Recruiting Contact: Site Public Contact
808-487-7447

Facility: Island Urology-Hilo
Hilo, Hawaii 96720
United States
Status: Recruiting Contact: Site Public Contact
808-536-2306

Facility: Hawaii Cancer Care Inc-POB II
Honolulu, Hawaii 96813
United States
Status: Recruiting Contact: Site Public Contact
808-524-6115

Facility: Island Urology
Honolulu, Hawaii 96813
United States
Status: Recruiting Contact: Site Public Contact
808-536-2306
virginia@cc.hawaii.edu

Facility: Queen's Cancer Cenrer - POB I
Honolulu, Hawaii 96813
United States
Status: Recruiting Contact: Site Public Contact
808-532-0315

Facility: Queen's Medical Center
Honolulu, Hawaii 96813
United States
Status: Recruiting Contact: Site Public Contact
808-545-8548

Facility: Straub Clinic and Hospital
Honolulu, Hawaii 96813
United States
Status: Recruiting Contact: Site Public Contact
808-522-4333

Facility: University of Hawaii Cancer Center
Honolulu, Hawaii 96813
United States
Status: Recruiting Contact: Site Public Contact
808-586-2979

Facility: Queen's Cancer Center - Kuakini
Honolulu, Hawaii 96817
United States
Status: Recruiting Contact: Site Public Contact
808-531-8521

Facility: Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
United States
Status: Recruiting Contact: Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Facility: Saint Luke's Mountain States Tumor Institute
Boise, Idaho 83712
United States
Status: Recruiting Contact: Site Public Contact
208-381-2774
eslinget@slhs.org

Facility: Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
United States
Status: Recruiting Contact: Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Facility: Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho 83619
United States
Status: Recruiting Contact: Site Public Contact
208-381-2774
eslinget@slhs.org

Facility: Saint Luke's Cancer Institute - Meridian
Meridian, Idaho 83642
United States
Status: Recruiting Contact: Site Public Contact
208-381-2774
eslinget@slhs.org

Facility: Saint Alphonsus Medical Center-Nampa
Nampa, Idaho 83686
United States
Status: Recruiting Contact: Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Facility: Saint Luke's Cancer Institute - Nampa
Nampa, Idaho 83686
United States
Status: Recruiting Contact: Site Public Contact
208-381-2774
eslinget@slhs.org

Facility: Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho 83301
United States
Status: Recruiting Contact: Site Public Contact
208-381-2774
eslinget@slhs.org

Facility: Centralia Oncology Clinic
Centralia, Illinois 62801
United States
Status: Recruiting Contact: Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Facility: Northwestern University
Chicago, Illinois 60611
United States
Status: Recruiting Contact: Site Public Contact
312-695-1301
cancer@northwestern.edu

Facility: University of Illinois
Chicago, Illinois 60612
United States
Status: Recruiting Contact: Site Public Contact
312-355-3046

Facility: Carle on Vermilion
Danville, Illinois 61832
United States
Status: Recruiting Contact: Site Public Contact
800-446-5532
Research@carle.com

Facility: Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
United States
Status: Recruiting Contact: Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Facility: Decatur Memorial Hospital
Decatur, Illinois 62526
United States
Status: Recruiting Contact: Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Facility: Carle Physician Group-Effingham
Effingham, Illinois 62401
United States
Status: Recruiting Contact: Site Public Contact
800-446-5532
Research@carle.com

Facility: Crossroads Cancer Center
Effingham, Illinois 62401
United States
Status: Recruiting Contact: Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Facility: Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United States
Status: Recruiting Contact: Site Public Contact
800-446-5532
Research@carle.com

Facility: Loyola University Medical Center
Maywood, Illinois 60153
United States
Status: Recruiting Contact: Site Public Contact
708-226-4357

Facility: Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
United States
Status: Recruiting Contact: Site Public Contact
618-242-4600

Facility: Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
United States
Status: Recruiting Contact: Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Facility: Southern Illinois University School of Medicine
Springfield, Illinois 62702
United States
Status: Recruiting Contact: Site Public Contact
217-545-7929

Facility: Springfield Clinic
Springfield, Illinois 62702
United States
Status: Recruiting Contact: Site Public Contact
800-444-7541

Facility: Memorial Medical Center
Springfield, Illinois 62781
United States
Status: Recruiting Contact: Site Public Contact
217-788-3528

Facility: Carle Cancer Center
Urbana, Illinois 61801
United States
Status: Recruiting Contact: Site Public Contact
800-446-5532
Research@carle.com

Facility: The Carle Foundation Hospital
Urbana, Illinois 61801
United States
Status: Recruiting Contact: Site Public Contact
800-446-5532
Research@carle.com

Facility: University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
United States
Status: Recruiting Contact: Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Facility: East Jefferson General Hospital
Metairie, Louisiana 70006
United States
Status: Recruiting Contact: Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Facility: LSU Healthcare Network / Metairie Multi-Specialty Clinic
Metairie, Louisiana 70006
United States
Status: Recruiting Contact: Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Facility: Louisiana State University Health Science Center
New Orleans, Louisiana 70112
United States
Status: Recruiting Contact: Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Facility: University Medical Center New Orleans
New Orleans, Louisiana 70112
United States
Status: Recruiting Contact: Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Facility: Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
United States
Status: Recruiting Contact: Site Public Contact
410-955-8804
jhcccro@jhmi.edu

Facility: Brigham and Women's Hospital
Boston, Massachusetts 02115
United States
Status: Recruiting Contact: Site Public Contact
617-724-5200

Facility: Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106
United States
Status: Recruiting Contact: Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Facility: University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
United States
Status: Recruiting Contact: Site Public Contact
800-865-1125

Facility: Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 48183
United States
Status: Recruiting Contact: Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Facility: Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
United States
Status: Recruiting Contact: Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Facility: Henry Ford Medical Center-Fairlane
Dearborn, Michigan 48126
United States
Status: Recruiting Contact: Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Facility: Henry Ford Hospital
Detroit, Michigan 48202
United States
Status: Recruiting Contact: Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Facility: Sparrow Hospital
Lansing, Michigan 48912
United States
Status: Recruiting Contact: Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Facility: Henry Ford Medical Center-Columbus
Novi, Michigan 48377
United States
Status: Recruiting Contact: Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Facility: Saint John Macomb-Oakland Hospital
Warren, Michigan 48093
United States
Status: Recruiting Contact: Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Facility: Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
United States
Status: Recruiting Contact: Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Facility: Saint Francis Medical Center
Cape Girardeau, Missouri 63703
United States
Status: Recruiting Contact: Site Public Contact
573-334-2230
sfmc@sfmc.net

Facility: Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
United States
Status: Recruiting Contact: Site Public Contact
314-251-7066

Facility: Mercy Hospital Springfield
Springfield, Missouri 65804
United States
Status: Recruiting Contact: Site Public Contact
417-269-4520

Facility: Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
United States
Status: Recruiting Contact: Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Facility: Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada 89052
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada 89052
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: OptumCare Cancer Care at Seven Hills
Henderson, Nevada 89052
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada 89074
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Las Vegas Urology - Green Valley
Henderson, Nevada 89074
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Las Vegas Urology - Pebble
Henderson, Nevada 89074
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Urology Specialists of Nevada - Green Valley
Henderson, Nevada 89074
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Las Vegas Urology - Pecos
Las Vegas, Nevada 89074
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: OptumCare Cancer Care at Oakey
Las Vegas, Nevada 89102
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Hope Cancer Care of Nevada
Las Vegas, Nevada 89103
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Urology Specialists of Nevada - Central
Las Vegas, Nevada 89106
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Las Vegas Prostate Cancer Center
Las Vegas, Nevada 89113
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Las Vegas Urology - Sunset
Las Vegas, Nevada 89113
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada 89128
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Las Vegas Urology - Cathedral Rock
Las Vegas, Nevada 89128
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Las Vegas Urology - Smoke Ranch
Las Vegas, Nevada 89128
United States
Status: Recruiting Contact: Site Public Contact
research@smcrf.org

Facility: OptumCare Cancer Care at MountainView
Las Vegas, Nevada 89128
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Urology Specialists of Nevada - Northwest
Las Vegas, Nevada 89128
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada 89144
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada 89144
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89148
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Urology Specialists of Nevada - Southwest
Las Vegas, Nevada 89148
United States
Status: Recruiting Contact: Site Public Contact
research@sncrf.org

Facility: Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada 89169
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Renown Regional Medical Center
Reno, Nevada 89502
United States
Status: Recruiting Contact: Site Public Contact
702-384-0013
research@sncrf.org

Facility: Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United States
Status: Recruiting Contact: Site Public Contact
212-639-7592

Facility: Englewood Hospital and Medical Center
Englewood, New Jersey 07631
United States
Status: Recruiting Contact: Site Public Contact
201-894-3456

Facility: Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United States
Status: Recruiting Contact: Site Public Contact
212-639-7592

Facility: Roswell Park Cancer Institute
Buffalo, New York 14263
United States
Status: Recruiting Contact: Site Public Contact
800-767-9355
askroswell@roswellpark.org

Facility: Memorial Sloan Kettering Commack
Commack, New York 11725
United States
Status: Recruiting Contact: Site Public Contact
212-639-7592

Facility: Memorial Sloan Kettering Westchester
Harrison, New York 10604
United States
Status: Recruiting Contact: Site Public Contact
212-639-7592

Facility: Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
United States
Status: Recruiting Contact: Site Public Contact
212-263-4434
prmc.coordinator@nyumc.org

Facility: Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Status: Recruiting Contact: Site Public Contact
212-639-7592

Facility: University of Rochester
Rochester, New York 14642
United States
Status: Recruiting Contact: Site Public Contact
585-275-5830

Facility: State University of New York Upstate Medical University
Syracuse, New York 13210
United States
Status: Recruiting Contact: Site Public Contact
315-464-5476

Facility: Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United States
Status: Recruiting Contact: Site Public Contact
212-639-7592

Facility: UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
United States
Status: Recruiting Contact: Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu

Facility: Indu and Raj Soin Medical Center
Beavercreek, Ohio 45431
United States
Status: Recruiting Contact: Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Facility: Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United States
Status: Recruiting Contact: Site Public Contact
800-293-5066
Jamesline@osumc.edu

Facility: Kettering Medical Center
Kettering, Ohio 45429
United States
Status: Recruiting Contact: Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Facility: University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
United States
Status: Recruiting Contact: Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Facility: Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
United States
Status: Recruiting Contact: Site Public Contact
405-752-3402

Facility: Bay Area Hospital
Coos Bay, Oregon 97420
United States
Status: Recruiting Contact: Site Public Contact
541-269-8392
cherie.cox@bayareahospital.org

Facility: Rogue Valley Medical Center
Medford, Oregon 97504
United States
Status: Recruiting Contact: Site Public Contact
541-789-6176

Facility: Saint Alphonsus Medical Center-Ontario
Ontario, Oregon 97914
United States
Status: Recruiting Contact: Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Facility: Oregon Health and Science University
Portland, Oregon 97239
United States
Status: Recruiting Contact: Site Public Contact
503-494-1080
trials@ohsu.edu

Facility: Portland VA Medical Center
Portland, Oregon 97239
United States
Status: Recruiting Contact: Site Public Contact
800-949-1004

Facility: Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
United States
Status: Recruiting Contact: Site Public Contact
215-955-6084

Facility: Ralph H Johnson VA Medical Center
Charleston, South Carolina 29401
United States
Status: Recruiting Contact: Site Public Contact
843-789-7020
ashley.salvo@va.gov

Facility: Prisma Health Cancer Institute - Laurens
Clinton, South Carolina 29325
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Cancer Institute - Easley
Easley, South Carolina 29640
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Cancer Institute - Butternut
Greenville, South Carolina 29605
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Cancer Institute - Faris
Greenville, South Carolina 29605
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Greenville Memorial Hospital
Greenville, South Carolina 29605
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Cancer Institute - Eastside
Greenville, South Carolina 29615
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Cancer Institute - Greer
Greer, South Carolina 29650
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Cancer Institute - Seneca
Seneca, South Carolina 29672
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: Prisma Health Cancer Institute - Spartanburg
Spartanburg, South Carolina 29307
United States
Status: Recruiting Contact: Site Public Contact
864-522-2066
kim.williams3@prismahealth.org

Facility: UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
United States
Status: Recruiting Contact: Site Public Contact
214-648-7097
canceranswerline@UTSouthwestern.edu

Facility: University of Texas Medical Branch
Galveston, Texas 77555-0565
United States
Status: Recruiting Contact: Site Public Contact
409-772-1950
clinical.research@utmb.edu

Facility: Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas 77030
United States
Status: Recruiting Contact: Site Public Contact
713-798-1354
burton@bcm.edu

Facility: Houston Methodist Hospital
Houston, Texas 77030
United States
Status: Recruiting Contact: Site Public Contact
713-790-2700

Facility: M D Anderson Cancer Center
Houston, Texas 77030
United States
Status: Recruiting Contact: Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Facility: UTMB Cancer Center at Victory Lakes
League City, Texas 77573
United States
Status: Recruiting Contact: Site Public Contact
800-917-8906

Facility: Audie L Murphy VA Hospital
San Antonio, Texas 78229
United States
Status: Recruiting Contact: Site Public Contact
877-469-5300

Facility: University of Texas Health Science Center at San Antonio
San Antonio, Texas 78229
United States
Status: Recruiting Contact: Site Public Contact
210-450-3800
phoresearchoffice@uthscsa.edu

Facility: Farmington Health Center
Farmington, Utah 84025
United States
Status: Recruiting Contact: Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Facility: Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
Status: Recruiting Contact: Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Facility: South Jordan Health Center
South Jordan, Utah 84009
United States
Status: Recruiting Contact: Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Facility: Fred Hutchinson Cancer Research Center
Seattle, Washington 98109
United States
Status: Recruiting Contact: Site Public Contact
800-804-8824

Facility: Seattle Cancer Care Alliance
Seattle, Washington 98109
United States
Status: Recruiting Contact: Site Public Contact
800-804-8824

Facility: University of Washington Medical Center
Seattle, Washington 98195
United States
Status: Recruiting Contact: Site Public Contact
800-804-8824

Facility: Madigan Army Medical Center
Tacoma, Washington 98431
United States
Status: Recruiting Contact: Site Public Contact
253-968-0129
mamcdci@amedd.army.mil

Facility: West Virginia University Healthcare
Morgantown, West Virginia 26506
United States
Status: Recruiting Contact: Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Facility: Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin 54729
United States
Status: Recruiting Contact: Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Facility: Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
United States
Status: Recruiting Contact: Site Public Contact
608-775-2385
cancerctr@gundersenhealth.org

Facility: Marshfield Clinic - Ladysmith Center
Ladysmith, Wisconsin 54848
United States
Status: Recruiting Contact: Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Facility: Medical College of Wisconsin
Milwaukee, Wisconsin 53226
United States
Status: Recruiting Contact: Site Public Contact
414-805-3666

Facility: Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin 54482
United States
Status: Recruiting Contact: Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Facility: Marshfield Clinic-Wausau Center
Wausau, Wisconsin 54401
United States
Status: Recruiting Contact: Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Facility: Marshfield Clinic - Weston Center
Weston, Wisconsin 54476
United States
Status: Recruiting Contact: Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Facility: Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin 54494
United States
Status: Recruiting Contact: Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org