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Brief Title: Sasanlimab (PF-06801591) in Combination With Bacillus Calmette-Guerin (BCG) in Participants With High-Risk Non-Muscle Invasive Bladder Cancer

A Phase 3, Multinational, Randomized, Open-Label, Three Parallel-Arm Study of PF-06801591, an Anti-PD-1 Antibody, in Combination With Bacillus Calmette-Guerin (BCG Induction With or Without BCG Maintenance) Versus BCG (Induction and Maintenance) in Participants With High-Risk, BCG-Naïve Non-Muscle Invasive Bladder Cancer or PF-06801591 as a Single Agent in Participants With BCG-Unresponsive NMIBC

INTRODUCTION

  • Org Study ID: B8011006
  • Secondary ID: 2019-003375-19
  • NTC ID: NCT04165317
  • Sponsor: Pfizer
To obtain contact information for a study center near you, click here.

DESCRIPTION

The purpose of this study is to determine the safety and effects of study drug Sasanlimab with radiation therapy (High-dose hypo-fractionated radiation therapy) prior to surgery to remove the bladder (known as radical cystectomy, [RC]) in muscle invasive bladder cancer patients. For this type of cancer, patients typically receive either chemotherapy followed by RC as the standard of care or concurrent chemotherapy and radiation therapy as another well-established option. We are studying the use of study drug with the addition of radiation therapy as an alternative combined therapy for those who are ineligible or have declined to receive the standard cisplatin- based chemotherapy because of pre-existing medical conditions like poor kidney function. Additionally, the role of radiation therapy as a combined therapy has been well studied to help boost our immune cells to attack the cancer cells.

Although the radiation therapy is approved to treat bladder cancer in the United States, Sasanlimab is an investigational drug because it has not yet been approved for the use in this country. By giving both the study drug and radiation therapy together, researchers want to see if the combined therapy before surgery works better than having the surgery by itself. Sasanlimab will be referred to as “study drug” throughout the consent.

Bladder cancer is known to inhibit your immune cells (T-Cells) from attacking it, which is an important way in which our bodies control cancer cells. Sasanlimab is an antibody (called an immune checkpoint inhibitor) that allows the T-cells to become active again. This allows the T- cells to attack and kill bladder cancer cells. Ongoing studies have shown that drugs similar to Sasanlimab can be used to achieve improvement in cancer control in the bladder (as measured by shrinking the cancer or eradicating it) before surgery.

This study is designed as a Phase II clinical trial. This means that prior to this current study, clinical trials (Phase I) have already established the optimal dose and method to deliver the study drug. At this time, we are testing if this treatment works specifically for a certain type of cancer,which is muscle invasive bladder cancer for our clinical trial. Moreover, the stage of this clinical trial will also continue to provide more information about the safety of the study drug and how the treatment affects the body.

BRIEF SUMMARY

The purpose of this study is to learn about the safety and effects of the study medicine (sasanlimab) in people with non-muscle invasive bladder cancer. This study is seeking participants whose bladder cancer is still in early stages, has not spread outside of the bladder, has been removed with surgery, and is high risk (Part A) or was previously treated with BCG (Bacillus Calmette Guerin), a standard treatment for bladder cancer (Part B).

In Part A (enrollment closed), each participant was assigned to one of three study treatment groups.

One group is given sasanlimab and BCG at the study clinic.
The second group is given sasanlimab and BCG at the study clinic. This group will receive BCG for the first six weeks only.
The third group is given BCG only and will not receive sasanlimab.

In Part B of the study, each new participant will be assigned to a study treatment group based on the type of their bladder tumor.

- Both groups will be given sasanlimab at the study clinic.

DETAILED DESCRIPTION

CREST: Combination of sasanlimab and alternative BCG Regimens to Evaluate outcomes with Subcutaneous anti-PD-1 Treatment

Phase 3 Design with two Cohorts. Cohort A consists of 3 study Arms (A, B and C) of BCG naive participants. Arms A and B consist of two study drugs, PF-06801591 plus BCG. Arm C consists of one study drug, BCG. Cohort B consists of B1 and B2, which test PF-06801591 and include participants who have BCG unresponsive CIS (B1) or BCG unresponsive papillary only disease (B2).

The study is designed to demonstrate that PF-06801591 plus Bacillus Calmette Guerin (BCG) (induction and maintenance periods) is superior to BCG alone (induction and maintenance periods) in prolonging event free survival (EFS) in participants with high-risk naïve non-muscle invasive bladder cancer (NMIBC) and to demonstrate that PF-06801591 plus BCG (induction period only) is superior to BCG alone (induction and maintenance periods) in prolonging EFS in participants with high-risk NMIBC. The study is also designed to estimate the CR rate of PF-06801591 alone in participants with BCG unresponsive CIS and to evaluate the EFS of PF-06801591 alone in participants with BCG unresponsive NMIBC.

  • Overall Status
    Recruiting
  • Start Date
    December 30, 2019
  • Phase
    Phase 3
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Event free survival (Cohort A: Arm A compared to Arm C)

Primary Outcome 1 - Timeframe: 55 months after first participant randomized

Primary Outcome 2 - Measure: Event free survival (Cohort A: Arm B compared to Arm C)

Primary Outcome 2 - Timeframe: 55 months after first participant randomized

Primary Outcome 3 - Measure: Complete response rate (Cohort B1)

Primary Outcome 3 - Timeframe: Registration to 12 months after last participant initially assessed

Primary Outcome 4 - Measure: Event free survival (Cohort B2)

Primary Outcome 4 - Timeframe: Registration to 12 months after last participant initially assessed

CONDITION

  • Non-muscle Invasive Bladder Cancer

ELIGIBILITY

Inclusion Criteria:
Histological confirmed diagnosis of high risk non-muscle invasive transitional cell carcinoma (TCC) of the urothelium of the urinary bladder (tumors of mixed transitional/non-transitional cell histology are allowed, but TCC must be the predominant histology)

- Complete resection of all Ta/T1 papillary disease (including participants with concurrent CIS), with most recent positive TURBT occurring within 12 weeks prior to randomization or study intervention. A second TURBT must have been performed if indicated according to the current locally applicable guidelines, ie, American Urological Association, European Association of Urology

- (Cohorts B1 and B2 only): Histological confirmed diagnosis of BCG-unresponsive high-risk, non-muscle invasive TCC of the urothelium within 12 months (CIS only) or 6 months (recurrent Ta/T1 disease) of completion of adequate BCG therapy.

- Have refused or are ineligible for radical cystectomy
Exclusion Criteria:
Evidence of muscle-invasive, locally advanced or metastatic urothelial cancer or concurrent extravesical, non-muscle invasive TCC of the urothelium

- (Cohort A only): Intravesical BCG therapy within 2 years prior to randomization. Prior intravesical chemotherapy for NMIBC is allowed.
(Cohorts B1 and B2 only): Any systemic or intravesical chemotherapy or immunotherapy from the time of most recent positive TURBT to initiation of study intervention.
Prior immunotherapy with anti PD-1, anti PD-L1, anti PD-L2, or anti cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody

- Prior treatment with immunostimulatory agents including interleukin (IL)-2, IL-15, interferon (INF)

- Prior radiation therapy to the bladder

- (Cohorts B1 and B2 only): Prior participation in Cohort A of this study.

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Pfizer CT.gov Call Center

Role: Study Director

Affiliation: Pfizer

Overall Contact

Name: Pfizer CT.gov Call Center

Phone: 1-800-718-1021

Email: ClinicalTrials.gov_Inquiries@pfizer.com

LOCATION

Facility Status Contact
Facility: Urological Associates of Southern Arizona, P.C .
Tucson, Arizona 85715
United States
Status: Recruiting Contact: N/A
Facility: Urological Associates of Southern Arizona P.C.
Tucson, Arizona 85741
United States
Status: Recruiting Contact: N/A
Facility: Arkansas Urology
Little Rock, Arkansas 72211
United States
Status: Recruiting Contact: N/A
Facility: Centerview Surgery Center
Little Rock, Arkansas 72211
United States
Status: Recruiting Contact: N/A
Facility: Koman Family Outpatient Pavilion
La Jolla, California 92037
United States
Status: Recruiting Contact: N/A
Facility: Sulpizio Cardiovascular Center at UC San Diego Health
La Jolla, California 92037
United States
Status: Recruiting Contact: N/A
Facility: UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)
La Jolla, California 92037
United States
Status: Recruiting Contact: N/A
Facility: UC San Diego Moores Cancer Center
La Jolla, California 92093
United States
Status: Recruiting Contact: N/A
Facility: University of California Irvine Medical Center
Orange, California 92868
United States
Status: Recruiting Contact: N/A
Facility: UC San Diego Medical Center - Hillcrest
San Diego, California 92103
United States
Status: Recruiting Contact: N/A
Facility: The Urology Center of Colorado
Denver, Colorado 80211
United States
Status: Recruiting Contact: N/A
Facility: Urological Research Network Corp
Hialeah, Florida 33016
United States
Status: Recruiting Contact: N/A
Facility: UF Health Jacksonville
Jacksonville, Florida 32209
United States
Status: Recruiting Contact: N/A
Facility: UF Health North
Jacksonville, Florida 32218
United States
Status: Recruiting Contact: N/A
Facility: John H. Stroger, Jr. Hospital of Cook County/IND Pharmacy
Chicago, Illinois 60612
United States
Status: Recruiting Contact: N/A
Facility: John H. Stroger, Jr. Hospital of Cook County
Chicago, Illinois 60612
United States
Status: Recruiting Contact: N/A
Facility: DuPage Medical Group
Lisle, Illinois 60532
United States
Status: Recruiting Contact: N/A
Facility: DuPage Medical Group Ambulatory Surgery Center
Lombard, Illinois 60148
United States
Status: Recruiting Contact: N/A
Facility: DuPage Medical Group
Lombard, Illinois 60148
United States
Status: Recruiting Contact: N/A
Facility: Edward Hospital
Naperville, Illinois 60540
United States
Status: Recruiting Contact: N/A
Facility: Regional Urology Oncology & Radiation Center
Shreveport, Louisiana 71106
United States
Status: Recruiting Contact: N/A
Facility: Regional Urology, LLC
Shreveport, Louisiana 71106
United States
Status: Recruiting Contact: N/A
Facility: Chesapeake Urology Research Associates
Hanover, Maryland 21076
United States
Status: Recruiting Contact: N/A
Facility: Michigan Institute of Urology, PC
Troy, Michigan 48084
United States
Status: Recruiting Contact: N/A
Facility: Montefiore Medical Center - Montefiore Medical Park
Bronx, New York 10461
United States
Status: Recruiting Contact: N/A
Facility: Montefiore Medical Center - Oncology Investigational Services
Bronx, New York 10461
United States
Status: Recruiting Contact: N/A
Facility: Premier Medical Group of the Hudson Valley PC
New Windsor, New York 12553
United States
Status: Recruiting Contact: N/A
Facility: Bellevue Hospital
New York, New York 10016
United States
Status: Recruiting Contact: N/A
Facility: Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York 10016
United States
Status: Recruiting Contact: N/A
Facility: NYU Langone Medical Center (Tisch Hospital)
New York, New York 10016
United States
Status: Recruiting Contact: N/A
Facility: NYU Langone Health Urology Associates
New York, New York 10017
United States
Status: Recruiting Contact: N/A
Facility: Icahn School of Medicine at Mount Sinai
New York, New York 10029
United States
Status: Recruiting Contact: N/A
Facility: Mount Sinai Hospital
New York, New York 10029
United States
Status: Recruiting Contact: N/A
Facility: Dutchess Ambulatory Surgery Center
Poughkeepsie, New York 12601
United States
Status: Recruiting Contact: N/A
Facility: Premier Medical Group of the Hudson Valley PC
Poughkeepsie, New York 12603
United States
Status: Recruiting Contact: N/A
Facility: Associated Medical Professionals of New York, PLLC
Syracuse, New York 13210
United States
Status: Recruiting Contact: N/A
Facility: VA Portland Healthcare System
Portland, Oregon 97239
United States
Status: Recruiting Contact: N/A
Facility: Carolina Urologic Research Center
Myrtle Beach, South Carolina 29572
United States
Status: Recruiting Contact: N/A
Facility: Parkway Surgery Center
Myrtle Beach, South Carolina 29572
United States
Status: Recruiting Contact: N/A
Facility: Urology Clinics of North Texas
Dallas, Texas 75231
United States
Status: Recruiting Contact: N/A
Facility: Urology Clinics of North Texas
Dallas, Texas 75246
United States
Status: Recruiting Contact: N/A
Facility: Houston Metro Urology
Houston, Texas 77027
United States
Status: Recruiting Contact: N/A
Facility: Houston Methodist Hospital
Houston, Texas 77030
United States
Status: Recruiting Contact: N/A
Facility: Urology San Antonio PA
San Antonio, Texas 78229
United States
Status: Recruiting Contact: N/A
Facility: Sentara Norfolk General Hospital
Norfolk, Virginia 23507
United States
Status: Recruiting Contact: N/A
Facility: Urology of Virginia, PLLC
Virginia Beach, Virginia 23462
United States
Status: Recruiting Contact: N/A
Facility: Southern Highlands Cancer Centre
Bowral, New South Wales 2756
Australia
Status: Recruiting Contact: N/A
Facility: Campbelltown Hospital
Campbelltown, New South Wales 2560
Australia
Status: Recruiting Contact: N/A
Facility: Campbelltown Private Hospital
Campbelltown, New South Wales 2560
Australia
Status: Recruiting Contact: N/A
Facility: Chris O'Brien Lifehouse
Camperdown, New South Wales 2050
Australia
Status: Recruiting Contact: N/A
Facility: Box Hill Hospital
Box Hill, Victoria 3128
Australia
Status: Recruiting Contact: N/A
Facility: Eastern Clinical Research Unit
Box Hill, Victoria 3128
Australia
Status: Recruiting Contact: N/A
Facility: Yarra Ranges Health
Lilydale, Victoria 3140
Australia
Status: Recruiting Contact: N/A
Facility: UZ Gent
Gent, British Columbia 9000
Belgium
Status: Recruiting Contact: N/A
Facility: Vancouver Prostate Centre at the Vancouver General Hospital
Vancouver, Ontario V5Z 1M9
Canada
Status: Recruiting Contact: N/A
Facility: Hamilton Regional Laboratory Medicine Program
Hamilton, Ontario L8N 4A6
Canada
Status: Recruiting Contact: N/A
Facility: McMaster Institute of Urology/St Joseph's Healthcare Hamilton
Hamilton, Ontario L8N 4A6
Canada
Status: Recruiting Contact: N/A
Facility: Kingston Health Sciences Centre - Kingston General Hospital
Kingston, Ontario K7L 2V7
Canada
Status: Recruiting Contact: N/A
Facility: Centre for Applied Urological Research
Kingston, Ontario K7L 3J7
Canada
Status: Recruiting Contact: N/A
Facility: Kingston Health Sciences Centre -- Hotel Dieu Hospital
Kingston, Ontario K7L 5G2
Canada
Status: Recruiting Contact: N/A
Facility: University Health Network - Princess Margaret Cancer Centre
Toronto, Ontario M5G 2M9
Canada
Status: Recruiting Contact: N/A
Facility: University Health Network - Toronto General Hospital
Toronto, Quebec M5G2C4
Canada
Status: Recruiting Contact: N/A
Facility: Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-Saint-Jean
Chicoutimi, Quebec G7H 5H6
Canada
Status: Recruiting Contact: N/A
Facility: McGill University Health Centre
Montreal, Anhui H4A 3J1
Canada
Status: Recruiting Contact: N/A
Facility: Hotel-Dieu de Quebec - CHU de Quebec - Universite Laval
Quebec, Beijing G1R 2J6
Canada
Status: Recruiting Contact: N/A
Facility: Centre de recherche clinique et evaluative en oncologie (CRCEO)
Quebec, Beijing G1R 3S1
Canada
Status: Recruiting Contact: N/A
Facility: Beijing Chao-yang Hospital
Beijing, Beijing 100020
China
Status: Recruiting Contact: N/A
Facility: Peking University First Hospital
Beijing, Fujian 100034
China
Status: Recruiting Contact: N/A
Facility: Beijing Cancer Hospital
Beijing, Hubei 100142
China
Status: Recruiting Contact: N/A
Facility: Peking Union Medical College Hospital
Beijing, Hunan 100730
China
Status: Recruiting Contact: N/A
Facility: Fujian Medical University Affiliated First Hospital
Fuzhou, Jiangsu 350005
China
Status: Recruiting Contact: N/A
Facility: Second Affiliated Hospital of Suzhou University
Suzhou, Sichuan 215004
China
Status: Recruiting Contact: N/A
Facility: First Affiliated Hospital of Xi 'an Jiaotong University
Xi'an, Zhejiang 710061
China
Status: Recruiting Contact: N/A
Facility: West China Hospital of Sichuan University
Chengdu, Zhejiang 610041
China
Status: Recruiting Contact: N/A
Facility: Chongqing University Cancer Hospital
Chongqing, Turin 400030
China
Status: Recruiting Contact: N/A
Facility: The Second Hospital of Tianjin Medical University
Tianjin, Ehime 300211
China
Status: Recruiting Contact: N/A
Facility: Hôpital privé Antony (Pharmacy)
Antony, Fukuoka 92160
France
Status: Recruiting Contact: N/A
Facility: Hôpital Privé d'Antony
Antony, Gunma 92160
France
Status: Recruiting Contact: N/A
Facility: Clinique Belharra
Bayonne, Hokkaido 64100
France
Status: Recruiting Contact: N/A
Facility: Clinique Saint-Augustin
BORDEAUX Cedex, Kanagawa 33074
France
Status: Recruiting Contact: N/A
Facility: Institut Bergonié
Bordeaux Cedex, Osaka 33076
France
Status: Recruiting Contact: N/A
Facility: CHU de Bordeaux Hôpital Pellegrin
Bordeaux, Osaka 33000
France
Status: Recruiting Contact: N/A
Facility: Groupe Vivalto Sante - Clinique Pasteur-Lanroze- CFRO
Brest Cedex 2, Shizuoka 29229
France
Status: Recruiting Contact: N/A
Facility: Cabinet Privé d'urologie
Brest, Tokyo 29200
France
Status: Recruiting Contact: N/A
Facility: CHPB Keraudren
Brest, Gyeonggi-do 29200
France
Status: Recruiting Contact: N/A
Facility: Polyclinique de Limoges Site Emailleurs-Colombier
Limoges Cedex 1, Republic OF Mordovia 87038
France
Status: Recruiting Contact: N/A
Facility: Polyclinique de Limoges Site Chenieux
Limoges, Saint-petersburg 87000
France
Status: Recruiting Contact: N/A
Facility: Polyclinique de Gentilly
Nancy, Stavropolskiy KRAI 54100
France
Status: Recruiting Contact: N/A
Facility: Hôpital Bichat - Claude-Bernard
Paris, Vsevolozhsky District 75877
France
Status: Recruiting Contact: N/A
Facility: Clinique Sainte Anne
Strasbourg, Barcelona 67000
France
Status: Recruiting Contact: N/A
Facility: Urologicum Duisburg
Duisburg, Barcelona 47179
Germany
Status: Recruiting Contact: N/A
Facility: Klinikum der Goethe-Universitaet Frankfurt
Frankfurt, Barcelona 60590
Germany
Status: Recruiting Contact: N/A
Facility: Universitaetsklinikum Muenster, Urologie
Muenster, Barcelona 48149
Germany
Status: Recruiting Contact: N/A
Facility: Studienpraxis Urologie
Nuertingen, Madrid 72622
Germany
Status: Recruiting Contact: N/A
Facility: Universitaetsklinikum Tuebingen
Tuebingen, Navarra 72076
Germany
Status: Recruiting Contact: N/A
Facility: UO Oncologia, ASST di Cremona - Istituti Ospitalieri - Ospedale di Cremona
Cremona, 26100
Italy
Status: Recruiting Contact: N/A
Facility: IRCSS Istituto Clinico Humanitas - U.O. Oncologia Medica
Rozzano, 20089
Italy
Status: Recruiting Contact: N/A
Facility: AO Azienda Ospedaliera Ordine Mauriziano Di Torino
Torino, 10128
Italy
Status: Recruiting Contact: N/A
Facility: Ospedale Area Aretina Nord - UOC Oncologia Medica
Arezzo, 52100
Italy
Status: Recruiting Contact: N/A
Facility: UO Oncologia Medica IRCCS Istituto Tumori "Giovanni Paolo II"
Bari, 70124
Italy
Status: Recruiting Contact: N/A
Facility: IRCCS Azienda Ospedaliera Universitaria Policlinico San Martino Urologia
Genova, 16132
Italy
Status: Recruiting Contact: N/A
Facility: Ospedale Generale Provinciale di Macerata - UOC Oncologia
Macerata, 62100
Italy
Status: Recruiting Contact: N/A
Facility: IRCCS Ospedale San Raffaele, URI (Urological Research Institute)
Milan, 20132
Italy
Status: Recruiting Contact: N/A
Facility: AUSL/IRCCS di Reggio Emilia
Reggio Emilia, 42123
Italy
Status: Recruiting Contact: N/A
Facility: ASST Sette Laghi Ospedale di Circolo Fondazione Macchi
Varese, 21100
Italy
Status: Recruiting Contact: N/A
Facility: National Hospital Organization Shikoku Cancer Center
Matsuyama, 791-0280
Japan
Status: Recruiting Contact: N/A
Facility: Ehime University Hospital
Toon, 791-0295
Japan
Status: Recruiting Contact: N/A
Facility: National Hospital Organization Kyushu Cancer Center
Fukuoka-shi, 811-1395
Japan
Status: Recruiting Contact: N/A
Facility: Gunma Prefectural Cancer Center
Ota, 373-8550
Japan
Status: Recruiting Contact: N/A
Facility: National Hospital Organization Hokkaido Cancer Center
Sapporo, 003-0804
Japan
Status: Recruiting Contact: N/A
Facility: Kanagawa cancer center
Yokohama, 241-8515
Japan
Status: Recruiting Contact: N/A
Facility: Osaka International Cancer Institute
Osaka-shi, 541-8567
Japan
Status: Recruiting Contact: N/A
Facility: Kindai University Hospital
Osakasayama, 589-8511
Japan
Status: Recruiting Contact: N/A
Facility: Hamamatsu University Hospital
Hamamatsu, 431-3192
Japan
Status: Recruiting Contact: N/A
Facility: Keio University Hospital
Shinjuku-ku, 160-8582
Japan
Status: Recruiting Contact: N/A
Facility: Kagoshima University Hospital
Kagoshima, 890-8520
Japan
Status: Recruiting Contact: N/A
Facility: National Hospital Organization Kumamoto Medical Center
Kumamoto, 860-0008
Japan
Status: Recruiting Contact: N/A
Facility: Okayama Medical Center
Okayama, 701-1192
Japan
Status: Recruiting Contact: N/A
Facility: Yamagata University Hospital
Yamagata, 990-9585
Japan
Status: Recruiting Contact: N/A
Facility: National Cancer Center
Goyang-si, 10408
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Seoul National University Bundang Hospital
Seongnam-si, 13620
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Kyungpook National University Chilgok Hospital
Daegu, 41404
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Korea University Anam Hospital
Seoul, 02841
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Seoul National University Hospital
Seoul, 03080
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Severance Hospital, Yonsei University Health System
Seoul, 03722
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Samsung Medical Center
Seoul, 06351
Korea, Republic of
Status: Recruiting Contact: N/A
Facility: Szpital Wojewodzki im Jana Pawla II
Belchatow, 97-400
Poland
Status: Recruiting Contact: N/A
Facility: NZOZ AKMED Andrzej Kupilas
Gliwice, 44-100
Poland
Status: Recruiting Contact: N/A
Facility: Niepubliczny Zaklad Opieki Zdrowotnej Centrum Urologiczne Sp. z o.o.
Mysłowice, 41-400
Poland
Status: Recruiting Contact: N/A
Facility: Provita Profamilia
Piotrkow Trybunalski, 97-300
Poland
Status: Recruiting Contact: N/A
Facility: Clinical Research Center Spolka z ograniczona odpowiedzialnoscia MEDIC-R Spolka Komandytowa
Poznan, 60-848
Poland
Status: Recruiting Contact: N/A
Facility: Provita 001
Warszawa, 02-647
Poland
Status: Recruiting Contact: N/A
Facility: Medical Concierge Centrum Medyczne
Warszawa, 02-798
Poland
Status: Recruiting Contact: N/A
Facility: A.Tsyb Medical Research Radiological Center of the Ministry of Health of the Russian Federation
Obninsk, 249036
Russian Federation
Status: Recruiting Contact: N/A
Facility: State Budgetary Institution of Healthcare of the Republic of Mordovia
Saransk, 430032
Russian Federation
Status: Recruiting Contact: N/A
Facility: Private Medical Institution "Euromedservice"
Pushkin, 196603
Russian Federation
Status: Recruiting Contact: N/A
Facility: Klinika UZI 4D, LLC
Pyatigorsk, 357502
Russian Federation
Status: Recruiting Contact: N/A
Facility: State Budgetary Healthcare Institution "Leningrad Regional Clinical Oncology Dispensary"
Kuzmolovsky Settlement, 188663
Russian Federation
Status: Recruiting Contact: N/A
Facility: Evimed Llc
Chelyabinsk, 454048
Russian Federation
Status: Recruiting Contact: N/A
Facility: Regional Budgetary Healthcare Institution "Ivanovo Regional Oncology Dispensary"
Ivanovo, 153040
Russian Federation
Status: Recruiting Contact: N/A
Facility: Ars Medika Center, LLC
Kaliningrad, 236006
Russian Federation
Status: Recruiting Contact: N/A
Facility: Kaluga Regional Clinical Oncology Center
Kaluga, 248007
Russian Federation
Status: Recruiting Contact: N/A
Facility: P.A. Hertsen Moscow Oncology Research Center- branch of the National Medical Research
Moscow, 125284
Russian Federation
Status: Recruiting Contact: N/A
Facility: Federal Budgetary Institution of Healthcare "Privolzhsky District Medical Center of the Federal
Nizhny Novgorod, 603074
Russian Federation
Status: Recruiting Contact: N/A
Facility: BHI of Omsk region "Clinical Oncological Dispensary"
Omsk, 644013
Russian Federation
Status: Recruiting Contact: N/A
Facility: State Budgetary Institution of Ryazan Region "Regional Clinical Oncology Center"
Ryazan, 390011
Russian Federation
Status: Recruiting Contact: N/A
Facility: Joint-Stock Company "North-Western Centre of Evidence-Based Medicine" ("NWCoEBM" JSC)
Saint Petersburg, 194355
Russian Federation
Status: Recruiting Contact: N/A
Facility: Federal State Budgetary Healthcare Institution Saint - Petersburg
Saint-Petersburg, 194017
Russian Federation
Status: Recruiting Contact: N/A
Facility: Hospital OrKli LLC
Saint-Petersburg, 199178
Russian Federation
Status: Recruiting Contact: N/A
Facility: Republican Clinical Oncology Dispensary of the Ministry of Health of Bashkortostan Republic
Ufa, 450054
Russian Federation
Status: Recruiting Contact: N/A
Facility: Budgetary Healthcare Institution of Vologda region "Vologda Regional Clinical Hospital"
Vologda, 160022
Russian Federation
Status: Recruiting Contact: N/A
Facility: SBHI YaR Regional clinical oncology hospital
Yaroslavl, 150054
Russian Federation
Status: Recruiting Contact: N/A
Facility: Hospital Universitari Germans Trias i Pujol
Badalona, 08916
Spain
Status: Recruiting Contact: N/A
Facility: Hospital General de Granollers
Granollers, 08402
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, 08907
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Duran i Reynals- ICO L'Hospitalet
L'Hospitalet de Llobregat, 08908
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, 28222
Spain
Status: Recruiting Contact: N/A
Facility: Complejo Hospitalario de Navarra
Pamplona, 31008
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitari Sant Joan de Reus
Reus, 43204
Spain
Status: Recruiting Contact: N/A
Facility: Complejo Hospitalario Universitario A Coruna
A Coruna, 15006
Spain
Status: Recruiting Contact: N/A
Facility: Hospital del Mar
Barcelona, 08003
Spain
Status: Recruiting Contact: N/A
Facility: Fundacio Puigvert
Barcelona, 08025
Spain
Status: Recruiting Contact: N/A
Facility: Hospital de la Santa Creu i Sant Pau
Barcelona, 08041
Spain
Status: Recruiting Contact: N/A
Facility: Hospital San Pedro de Alcantara
Caceres, 10003
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitari de Girona Doctor Josep Trueta
Girona, 17007
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario Lucus Augusti
Lugo, 27003
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario de La Princesa
Madrid, 28006
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario La Princesa
Madrid, 28006
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Clínico San Carlos
Madrid, 28040
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Universitario 12 de Octubre
Madrid, 28041
Spain
Status: Recruiting Contact: N/A
Facility: Fundacion Instituto Valenciano de Oncologia
Valencia, 46009
Spain
Status: Recruiting Contact: N/A
Facility: Hospital Arnau de Vilanova
Valencia, 46015
Spain
Status: Recruiting Contact: N/A
Facility: Barts Health NHS Trust, St Bartholomew's Hospital
London, EC1A 7BE
United Kingdom
Status: Recruiting Contact: N/A
Facility: Charing Cross Hospital
London, W6 8RF
United Kingdom
Status: Recruiting Contact: N/A