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Brief Title: Tremelimumab, Durvalumab, and Belinostat for the Treatment of ARID1A Mutated Metastatic or Unresectable, Locally Advanced Urothelial Carcinoma

RESOLVE : A Phase I Trial of Tremelimumab + Durvalumab(MEDI4736)+ Belinostat in ARID1A Mutated Cancers With Focus on Urothelial Carcinoma

INTRODUCTION

  • Org Study ID: HCI143952
  • Secondary ID: NCI-2021-12484, HCI143952, P30CA042014
  • NTC ID: NCT05154994
  • Sponsor: University of Utah

BRIEF SUMMARY

This phase I trial studies the side effects and best dose of belinostat when given together with tremelimumab and durvalumab in treating patients with urothelial cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) and has spread to nearby tissue or lymph nodes (locally advanced). Immunotherapy with monoclonal antibodies, such as tremelimumab and durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Belinostat is a potential anti-cancer drug, known as a histone deacetylase (HDAC) inhibitor, which means that belinostat stops the activity of HDAC enzymes (an enzyme is a protein that in small amounts can speed up a biological reaction). HDAC enzymes play an important role in cell growth and cell death. Giving tremelimumab, durvalumab, and belinostat may improve the body's ability to fight cancer.

DETAILED DESCRIPTION

PRIMARY OBJECTIVES:

I. To assess the recommended phase 2 dose of belinostat in combination with tremelimumab and durvalumab in advanced solid tumors harboring ARID1A mutations with focus on urothelial carcinoma. (Phase 1A) II. To assess the ongoing safety of belinostat in combination with tremelimumab and durvalumab in patients with advanced solid tumors with ARID1A mutation with focus on urothelial cancer. (Phase 1B)

SECONDARY OBJECTIVES:

I. To assess the efficacy of belinostat in combination with tremelimumab and durvalumab in patients with advanced urothelial cancer with ARID1A mutation.

EXPLORATORY OBJECTIVES:

I. To assess the mechanism of action of belinostat in combination with tremelimumab and durvalumab.

II. To explore possible mechanisms of treatment resistance. III. To explore possible biomarkers predictive of treatment benefit.

OUTLINE: This is a dose-escalation study of belinostat.

Patients receive durvalumab intravenously (IV) over 30 minutes on day 1. Patients also receive tremelimumab IV over 60 minutes on day 1 of cycle 1. Beginning cycle 2, patients receive belinostat IV over 30 minutes on days 1-5. Treatment repeats every 21 days for 7 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive durvalumab IV over 30 minutes on day 1. Treatment repeats every 28 days for up to 24 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year and then every 6 months for 2 years.

  • Overall Status
    Recruiting
  • Start Date
    January 14, 2022
  • Phase
    Phase 1
  • Study Type
    Interventional

PRIMARY OUTCOMES

Primary Outcome 1 - Measure: Incidence of dose limiting toxicities (DLTs) (Phase 1A Part 1)

Primary Outcome 1 - Timeframe: Up to 21 days

Primary Outcome 2 - Measure: Incidence of DLTs (Phase 1A Part 2)

Primary Outcome 2 - Timeframe: Up to 21 days

Primary Outcome 3 - Measure: Incidence of adverse events (AEs) (Phase 1B)

Primary Outcome 3 - Timeframe: Up to 3 years

CONDITION

  • Infiltrating Urothelial Carcinoma
  • Sarcomatoid Variant
  • Locally Advanced Urothelial Carcinoma
  • Metastatic Urothelial Carcinoma
  • Unresectable Urothelial Carcinoma

ELIGIBILITY

Inclusion Criteria:
Male or female subject aged >= 18 years

- Histologically confirmed urothelial carcinoma with metastatic disease or with unresectable, locally advanced disease. Variant histology, including, but not limited to, neuroendocrine, sarcomatoid, and squamous differentiation are permitted to enroll
Patients must meet one or more of the following criteria:
Has progressed on at least one prior therapy; or

- Has declined standard therapy; or

- Is not a suitable candidate for standard therapy

- The discussion regarding the choice of standard therapy offered, if available, and patient's choice and reason(s) to decline standard therapy should be documented clearly in the research chart.

- Patients may have progressed on immune checkpoint inhibitor therapy

- Body weight > 30 kg
Malignancy harboring ARID1A loss of function (lof) genomic alterations as determined by the standard of care next-generation sequencing. Results must meet the following criteria:
Presence of a somatic alteration considered pathogenic/likely pathogenic in ARID1A gene as determined by genomic sequencing performed in a Clinical Laboratory Improvement Amendments (CLIA) laboratory

- Somatic alterations will include nonsense, frameshift, splice-site or missense mutations or gene deletions

- Subject must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria by computed tomography (CT) or magnetic resonance imaging (MRI)

- Eastern Cooperative Oncology Group (ECOG) performance status =< 1 - Absolute neutrophil count (ANC) >= 1500/mm^3

- Platelet count >= 100,000/mm^3

- Hemoglobin >= 10 g/dL

- Total Bilirubin =< 1.5 x institutional upper limit of normal (ULN)
Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x institutional ULN
Patients with liver metastases will be allowed to enroll with AST and ALT levels =< 5 x ULN - Estimated creatinine clearance >= 30 mL/min by Cockcroft-Gault formula
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients. Women will be considered post-menopausal if they have been amenorrheic for 12 months without an alternative medical cause. The following age-specific requirements apply:
Women < 50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy) - Women >= 50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses > 1 year ago, had chemotherapy-induced menopause with last menses > 1 year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)

- Highly effective contraception for both male and female subjects throughout the study and at least 4 months after last study treatment administration

- Recovery to baseline or =< grade 1 Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0 from toxicities related to any prior treatments, unless adverse event (AE)(s) are clinically non-significant and/or stable on supportive therapy - Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines - Estimated life expectancy of at least 12 weeks
Exclusion Criteria:
Homozygous for UGT1A1*28 allele or Gilbert syndrome

- Subject has received systemic antineoplastic therapy (including unconjugated therapeutic antibodies and toxin immunoconjugates) or any investigational therapy =< 14 days or within 5 half-lives before starting study treatment, whichever is shorter - Prior treatment with durvalumab plus tremelimumab - Subject has received radiotherapy =< 14 days before the first dose of study treatment. Localized radiation therapy for the treatment of symptomatic bone metastasis is allowed during that timeframe - Subjects who have undergone major surgery =< 3 weeks before starting study drug or who have not fully recovered from major surgery - Diagnosis of any other malignancy within 2 years before study enrollment, except for adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the breast, bladder or of the cervix, and prostate cancer on surveillance with no plans for treatment intervention (e.g., surgery, radiation, or castration) or prostate cancer that has been adequately treated with prostatectomy or radiotherapy and currently with no evidence of disease or symptoms is allowed
Known brain metastases or cranial epidural disease
Note: Brain metastases or cranial epidural disease adequately treated with radiotherapy and/or surgery and stable for at least 4 weeks before the first dose of study treatment will be allowed on trial. Subjects must be neurologically asymptomatic and without corticosteroid treatment at the time of the first dose of study treatment
Current evidence of uncontrolled, clinically significant intercurrent illness including, but not limited to, the following conditions:
Cardiovascular disorders:
Congestive heart failure New York Heart Association Class 3 or 4, unstable angina pectoris, serious cardiac arrhythmias

- Stroke (including transient ischemic attack [TIA]), myocardial infarction (MI), or other ischemic events, or thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism) within 3 months before the first dose
Uncontrolled hypertension defined as a sustained systolic blood pressure >= 160 mmHg or a diastolic blood pressure >= 100 mmHg despite optimal management
Note: Patients with uncontrolled hypertension who are not optimally managed may be rescreened once controlled hypertension is achieved
Patients with uncorrectable prolonged corrected QT (QTc) (Bezet formula) > 480 msec or concomitant use of medications(s) with a known risk of inducing Torsade de Pointes if such treatment cannot be discontinued or switched to a different medication before starting the study drug
Note: If a single electrocardiogram (ECG) shows a QTc with an absolute value > 480 msec, two additional ECGs approximately 2 minutes apart must be performed within 30 minutes of the initial ECG, and the average of these three consecutive results for QTc will be used

- Adrenal insufficiency

- Interstitial lung disease (ILD)

- Subjects with congenital long QT syndrome

- Patients currently on or who will require valproic acid for any medical condition during the study
Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [except for diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis, hypophysitis, uveitis, etc.]). The following are exceptions to this criterion:
Patients with vitiligo or alopecia

- Patients with hypothyroidism (e.g., following Hashimoto syndrome) stable on hormone replacement

- Any chronic skin condition that does not require systemic therapy

- Patients without active disease in the last 5 years may be included but only after consultation with the principal investigator

- Patients with celiac disease controlled by diet alone
Current or prior use of immunosuppressive medication within 14 days of cycle one day one, EXCEPT for the following permitted steroids:
Intranasal, inhaled, topical steroids, eye drops or local steroid injection (e.g., intra-articular injection);

- Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; - Steroids as premedication for hypersensitivity reactions (e.g., computed tomography (CT) scan premedication) - History of active primary immunodeficiency
Known human immunodeficiency virus (HIV) infection with a detectable viral load at the time of screening
Note: Patients on effective antiretroviral therapy with an undetectable viral load at the time of screening are eligible for this trial
Active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination, and radiographic findings, and tuberculosis (TB) testing in line with local practice), hepatitis B (known positive hepatitis B virus [HBV] surface antigen (HBsAg) result), or hepatitis C
Note: Patients with a past or resolved HBV infection (defined as the presence of hepatitis B core antibody [anti-HBc] and absence of HBsAg) are eligible. Patients positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV ribonucleic acid (RNA)

- Live attenuated vaccinations within 4 weeks of cycle one day one and while on trial is prohibited

- Known prior severe hypersensitivity to investigational product or any component in its formulations, including known severe hypersensitivity reactions to monoclonal antibodies (National Cancer Institute [NCI] CTCAE version [v]5.0 grade >= 3)

- Subjects taking prohibited medications. A washout period of prohibited medications for a period of at least 5 half-lives or as clinically indicated should occur before the start of treatment

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

OFFICIAL INFORMATION

Name: Sumati V Gupta

Role: Principal Investigator

Affiliation: Huntsman Cancer Institute/ University of Utah

Overall Contact

Name: Sumati V Gupta

Phone: 801-585-3453

Email: susan.sharry@hci.utah.edu

LOCATION

Facility Status Contact
Facility: Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United States
Status: Recruiting Contact: Contact
Sumati V. Gupta
801-213-5727
sumati.gupta@hci.utah.edu