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Antibody-drug conjugate (ADC)


Metastatic Bladder Cancer (includes T4 tumors)

Treatment Category:



Antibody-drug conjugate (ADC) (Chemotherapy + monoclonal antibody)

Suitable for:
  • Suitable for people with advanced bladder cancer who have already been treated with chemotherapy and another immunotherapy
  • Also suitable for people who can’t have chemotherapy but have already received at least one other type of drug therapy
How it works:
  • These therapies work by connecting a monoclonal antibody to a chemotherapy drug. Monoclonal antibodies work as part of our immune system to recognize specific parts of the bladder cancer cell
  • When a chemotherapy drug is attached to a monoclonal antibody, the chemotherapy can be targeted to bladder cancer cells so that it can find and kill these without damaging healthy cells
How it is typically used:

Usually given as a treatment for advanced bladder cancer that has continued to progress following treatment with other drug therapies, including chemotherapy and immune checkpoint inhibitors

How it is administered:

Administered as an infusion directly into a vein

Side effects:
  • Fatigue
  • Nerve damage that causes numbness or tingling in hands and feet
  • Nausea
  • Taste changes
  • Decreased appetite
  • Diarrhea
  • Rash
  • Hair loss
  • Dry eyes or vision changes
  • Dry skin
  • Itching
  • High blood sugar levels

Disclaimer: Information and services provided by the Bladder Cancer Advocacy Network (BCAN) are for informational purposes only. The information and services are not intended to be substitutes for professional medical advice, diagnosis or treatment. If you are ill, or suspect that you are ill, seek professional medical attention immediately! BCAN does not recommend or endorse any specific physicians, treatments, procedures or products even though they may be mentioned on this site.

  • You can search for a clinical trial by bladder cancer disease state, state of residence and you can also look for trials nearest to you.

  • Our interactive map shows the total numbers of cases anticipated in each of the 50 states as well as additional helpful bladder cancer resources in each state.